Chemoselective three-component synthesis of α-carbolines under metal-free conditions

被引：6

作者：

Feng, Wei ^{[1
]}

Zhang, Chao ^{[1
]}

Zhou, Xinlin ^{[1
]}

You, Kuiyi ^{[2
]}

Deng, Guo-Jun ^{[1
,3
]}

Chen, Shanping ^{[1
]}

机构：

[1] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China

[2] Xiangtan Univ, Sch Chem Engn, Xiangtan 411105, Peoples R China

[3] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 21期

基金：

中国国家自然科学基金;

关键词：

MULTICOMPONENT REACTIONS; BETA; DERIVATIVES; ACID; MESCENGRICIN; PYRIDINES; ANALOGS; POTENT; AGENTS;

D O I：

10.1039/d3qo01274c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An I2O5-promoted three-component tandem reaction for the rapid construction of alpha-carbolines has been described. The present approach starts from easily available starting materials, chemoselectively producing various alpha-carbolines in satisfactory yields under simple and metal-free conditions. Most importantly, this strategy can provide anticancer active molecules in one step on the gram scale. An I2O5-promoted chemoselective three-component tandem reaction of indole-3-carboxaldehydes, ammonium acetate, and alkynes for the construction of alpha-carbolines under metal-free conditions has been described.

引用

页码：5457 / 5462

页数：6

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