ABBV-383, a BCMA-CD3 bispecific antibody, in relapsed/refractory multiple myeloma: a multicenter, phase 1b dose optimization study with step-up dosing

被引:0
|
作者
Baljevic, Muhamed [1 ]
Magen, Hila [2 ,3 ]
Searle, Emma [4 ,5 ]
Jin, Ziyi [6 ]
Strange, Elise [6 ]
Svensson, Anders [6 ]
Kumar, Shaji [7 ]
机构
[1] Vanderbilt Univ, Med Ctr, Vanderbilt Ingram Canc Ctr, Nashville, TN USA
[2] Chaim Sheba Med Ctr, Ramat Gan, Israel
[3] Tel Aviv Univ, Sackler Fac Med, Tel Aviv, Israel
[4] Christie Hosp NHS Fdn Trust, Manchester, England
[5] Univ Manchester, Manchester, England
[6] AbbVie Inc, N Chicago, IL USA
[7] Mayo Clin, Rochester, MN USA
来源
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P-231
引用
收藏
页码:S162 / S163
页数:2
相关论文
共 50 条
  • [31] MagnetisMM-1: A Study of Elranatamab (PF-06863135), a B-Cell Maturation Antigen (BCMA)-Targeted, CD3-Engaging Bispecific Antibody, for Patients with Relapsed or Refractory Multiple Myeloma (MM)
    Levy, Moshe
    Bahlis, Nizar
    Raje, Noopur
    Costello, Caitlin
    Dholaria, Bhagirathbhai
    Solh, Melhem
    Tomasson, Michael
    Dube, Harman
    Damore, Michael
    Lon, Hoi Kei
    Basu, Cynthia
    Skoura, Athanasia
    Chan, Edward
    Trudel, Suzanne
    Jakubowiak, Andrzej
    Chu, Michael
    Gasparetto, Cristina
    Dalovisio, Andrew
    Sebag, Michael
    Lesokhin, Alexander
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S439 - S439
  • [32] Results from a first-in-human phase I study of F182112, a B-cell maturation antigen (BCMA)-CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma.
    Sun, Mingyuan
    Qiu, Lugui
    Wei, Yongqiang
    Jin, Jie
    Li, Xin
    Liu, Xue
    Yin, Shaohong
    Qi, Junyuan
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [33] Open-Label, Multicenter, Dose Escalation Phase 1b Study to Assess the Subcutaneous Delivery of Daratumumab in Patients (pts) with Relapsed or Refractory Multiple Myeloma (PAVO)
    Usmani, Saad Z.
    Nahi, Hareth
    Mateos, Maria-Victoria
    Lokhorst, Henk M.
    Chari, Ajai
    Kaufman, Jonathan L.
    Moreau, Philippe
    Oriol, Albert
    Plesner, Torben
    Benboubker, Lotfi
    Hellemans, Peter
    Masterson, Tara
    Clemens, Pamela L.
    Ahmadi, Tahamtan
    Liu, Kevin
    San-Miguel, Jesus
    BLOOD, 2016, 128 (22)
  • [34] Subcutaneous Delivery of Daratumumab in Patients (pts) with Relapsed or Refractory Multiple Myeloma (RRMM): Pavo, an Open-Label, Multicenter, Dose Escalation Phase 1b Study
    Chari, Ajai
    Nahi, Hareth
    Mateos, Maria-Victoria
    Lokhorst, Henk M.
    Kaufman, Jonathan L.
    Moreau, Philippe
    Oriol, Albert
    Plesner, Torben
    Benboubker, Lotfi
    Hellemans, Peter
    Masterson, Tara
    Clemens, Pamela L.
    Liu, Kevin
    San-Miguel, Jesus F.
    Usmani, Saad Z.
    BLOOD, 2017, 130
  • [35] Elranatamab, a B-cell maturation antigen (BCMA)-CD3 bispecific antibody, for patients (pts) with relapsed/refractory multiple myeloma (RRMM): Extended follow up and biweekly administration from the MagnetisMM-3 study.
    Mohty, Mohamad
    Tomasson, Michael H.
    Arnulf, Bertrand
    Bahlis, Nizar J.
    Prince, H. Miles
    Niesvizky, Ruben
    Rodriguez-Otero, Paula
    Martinez-Lopez, Joaquin
    Koehne, Guenther
    Jethava, Yogesh
    Gabayan, A. Eli
    Stevens, Don A.
    Nooka, Ajay K.
    Raje, Noopur S.
    Iida, Shinsuke
    Leip, Eric
    Conte, Umberto
    Czibere, Akos Gabor
    Viqueira, Andrea
    Lesokhin, Alexander M.
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [36] A novel Immunotherapy Combination in relapsed/refractory Multiple Myeloma: Updated Analysis of Phase 1b Data for Talquetamab, a GPRC5DxCD3 bispecific Antibody, in Combination with Daratumumab
    Kortuem, K. M.
    Bahlis, N.
    Mateos, M. -V.
    Weisel, K.
    Dholaria, B.
    Garfall, A.
    Goldschmidt, H.
    Martin, T.
    Morillo, D.
    Reece, D.
    Hurd, D.
    Rodriguez-Otero, P.
    Bhutani, M.
    D'Souza, A.
    Oriol, A.
    Askari, E.
    San-Miguel, J.
    van de Donk, N.
    Vishwamitra, D.
    Lin, Wang S. X.
    Prior, T.
    Vandenberk, L.
    Smit, Damiette M. -A.
    Goldberg, J.
    Waesch, R.
    Chari, A.
    ONCOLOGY RESEARCH AND TREATMENT, 2022, 45 (SUPPL 2) : 144 - 145
  • [37] Long-Term Follow-Up From MajesTEC-1 of Teclistamab, a B-Cell Maturation Antigen (BCMA) x CD3 Bispecific Antibody, in Patients With Relapsed/Refractory Multiple Myeloma (RRMM)
    van de Donk, Niels
    Moreau, Philippe
    Garfall, Alfred
    Bhutani, Manisha
    Oriol, Albert
    Nooka, Ajay
    Martin, Thomas
    Rosinol, Laura
    Mateos, Maria-Victoria
    Bahlis, Nizar
    Popat, Rakesh
    Besemer, Britta
    Martinez Lopez, Joaquin
    Krishnan, Amrita
    Delforge, Michel
    Trancucci, Danielle
    Verona, Raluca
    Stephenson, Tara
    Chastain, Katherine
    Sidana, Surbhi
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2023, 23 : S477 - S478
  • [38] Long-term follow-up from MajesTEC-1 of Teclistamab, a B-cell Maturation Antigen (BCMA) x CD3 Bispecific Antibody, in patients with Relapsed/Refractory Multiple Myeloma (RRMM)
    Donk, Van De N. W.
    Moreau, P.
    Garfall, A. L.
    Bhutani, M.
    Oriol, A.
    Nooka, A. K.
    Martin, T. G.
    Rosinol, L.
    Mateos, M. -V.
    Bahlis, N.
    Popat, R.
    Besemer, B.
    Lopez, Martinez J.
    Krishnan, A.
    Delforge, M.
    Trancucci, D.
    Verona, R., I
    Stephenson, T.
    Chastain, K.
    Sidana, S.
    ONCOLOGY RESEARCH AND TREATMENT, 2023, 46 : 124 - 124
  • [39] Long-term follow-up from MajesTEC-1 of teclistamab, a B-cell maturation antigen (BCMA) x CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma (RRMM).
    van de Donk, Niels W. C. J.
    Moreau, Philippe
    Garfall, Alfred L.
    Bhutani, Manisha
    Oriol, Albert
    Nooka, Ajay K.
    Martin, Thomas G.
    Rosinol, Laura
    Mateos, Maria-Victoria
    Bahlis, Nizar J.
    Popat, Rakesh
    Besemer, Britta
    Martinez-Lopez, Joaquin
    Krishnan, Amrita Y.
    Delforge, Michel
    Trancucci, Danielle
    Verona, Raluca
    Stephenson, Tara
    Chastain, Katherine
    Sidana, Surbhi
    JOURNAL OF CLINICAL ONCOLOGY, 2023, 41 (16)
  • [40] LEMZOPARLIMAB (TJ011133), AN ANTI-CD47 ANTIBODY, WITH/WITHOUT DEXAMETHASONE PLUS ANTI-MYELOMA REGIMENS FOR RELAPSED/REFRACTORY MULTIPLE MYELOMA: A PHASE 1B DOSE ESCALATION AND EXPANSION STUDY
    Stadtmauer, Edward
    Karlin, Lionel
    Weisel, Katja
    Gatt, Moshe Etzion
    Kansagra, Ankit
    Monohan, Gregory
    Yee, Andrew
    Rockow-Magnone, Shayna
    Cordero, Jose
    Hoffman, David
    Bueno, Orlando
    Wu, Kevin
    Gasparetto, Cristina
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2021, 9 : A476 - A476