Highly Reliable Chiral Discrimination of Tryptophan Enantiomers through Two Different Modes: Electrochemistry and Temperature

Reliablechiral discrimination of enantiomers with simpledevicesis of great importance for chiral analysis. Here, a chiral sensingplatform is developed for chiral discrimination through two differentmodes: electrochemistry and temperature. Au nanoparticles (AuNPs)are grown in situ on the nanosheets of MXene by utilizing the strongmetal reduction ability of MXene, which can be further used for theanchoring of N-acetyl-l-cysteine (NALC),a commonly used chiral source, through Au-S bonds. Owing tothe excellent electrical conductivity and photothermal conversionefficiency of MXene, the resultant MXene-AuNPs-NALC is applied inthe construction of a chiral sensing platform for the discriminationof tryptophan (Trp) enantiomers through two different modes: electrochemistryand temperature. Compared with conventional single-mode chiral sensors,the proposed chiral sensing platform can integrate two different indicators(currents and temperature) into one chiral sensor, greatly improvingthe reliability of chiral discrimination.