Hepatic soluble epoxide hydrolase A promising target for unveiling the liver-brain axis in Alzheimer's disease

被引：1
|
作者：
Inoue, Yasuteru [1 ]
Bamkole, Michael [1 ]
Kanekiyo, Takahisa [1 ]
机构：
[1] Mayo Clin, Dept Neurol, Jacksonville, FL 32224 USA
来源：
NEURON | 2023年 / 111卷 / 18期
关键词：
PATHOLOGY;
D O I：
10.1016/j.neuron.2023.08.019
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Wu and Dong et al.(1) report that hepatic soluble epoxide hydrolase (sEH) manipulation impacts amyloid-beta (A beta) deposits and cognitive impairment in mouse models for Alzheimer's disease (AD), suggesting that hepatic sEH activity is a promising therapeutic target to treat AD.
引用
收藏
页码：2775 / 2777
页数：3
相关论文
共 50 条
  • [31] Gut-Brain Axis: Unveiling the Interplay Between Diabetes Mellitus and Alzheimer's Disease
    Haripriya, S.
    Tamilanban, T.
    Vellapandian, Chitra
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2024, 16 (08)
  • [32] An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer's disease
    Ghosh, Anamitra
    Comerota, Michele M.
    Wan, Debin
    Chen, Fading
    Propson, Nicholas E.
    Hwang, Sung Hee
    Hammock, Bruce D.
    Zheng, Hui
    SCIENCE TRANSLATIONAL MEDICINE, 2020, 12 (573)
  • [33] Potential cytotoxic role of epoxide hydrolase (EH) in Alzheimer's disease(AD).
    Gabbita, SP
    Hensley, K
    Floyd, RA
    Nael, R
    Markesbery, WR
    Mou, S
    Williamson, K
    Zheng, N
    Bing, G
    FREE RADICAL BIOLOGY AND MEDICINE, 1999, 27 : S139 - S139
  • [34] The Pharmacology of the Cytochrome P450 Epoxygenase/Soluble Epoxide Hydrolase Axis in the Vasculature and Cardiovascular Disease
    Fleming, Ingrid
    PHARMACOLOGICAL REVIEWS, 2014, 66 (04) : 1106 - 1140
  • [35] Neuroprotective Epigenetic Changes Induced by Maternal Treatment with an Inhibitor of Soluble Epoxide Hydrolase Prevents Early Alzheimer's Disease Neurodegeneration
    Bartra, Clara
    Irisarri, Alba
    Villoslada, Ainhoa
    Corpas, Ruben
    Aguirre, Samuel
    Garcia-Lara, Elisa
    Sunol, Cristina
    Pallas, Merce
    Grinan-Ferre, Christian
    Sanfeliu, Coral
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
  • [36] Imbalance of Epoxide and Diol Lipid Mediators in Alcoholic Liver Disease: Effects of Soluble Epoxide Hydrolase Inhibition in Experimental Mice
    Warner, Jeffrey
    Dastidar, Shubha Ghosh
    Warner, Dennis
    Song, Ying
    McClain, Craig J.
    Kirpich, Irina A.
    HEPATOLOGY, 2018, 68 : 816A - 817A
  • [37] Discovery and In Vivo Proof of Concept of a Highly Potent DualInhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase forthe Treatment of Alzheimer's Disease
    Codony, Sandra
    Pont, Caterina
    Grinan-Ferre, Christian
    Di Pede-Mattatelli, Ania
    Calvo-Tusell, Carla
    Feixas, Ferran
    Osuna, Silvia
    Jarne-Ferrer, Julia
    Naldi, Marina
    Bartolini, Manuela
    Isabel Loza, Maria
    Brea, Jose
    Perez, Belen
    Bartra, Clara
    Sanfeliu, Coral
    Juarez-Jimenez, Jordi
    Morisseau, Christophe
    Hammock, Bruce D.
    Pallas, Merce
    Vazquez, Santiago
    Munoz-Torrero, Diego
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (06) : 4909 - 4925
  • [38] Is Alzheimer's Disease a Liver Disease of the Brain?
    Bassendine, Margaret F.
    Taylor-Robinson, Simon D.
    Fertleman, Michael
    Khan, Michael
    Neely, Dermot
    JOURNAL OF ALZHEIMERS DISEASE, 2020, 75 (01) : 1 - 14
  • [39] The Brain's Microvascular Response to High Glycemia and to the Inhibition of Soluble Epoxide Hydrolase Is Sexually Dimorphic
    Nuthikattu, Saivageethi
    Milenkovic, Dragan
    Norman, Jennifer E.
    Rutledge, John
    Villablanca, Amparo
    NUTRIENTS, 2022, 14 (17)
  • [40] Inhibitors of soluble epoxide hydrolase and cGAS/STING repair defects in amyloid-β clearance underlying vascular complications of Alzheimer's disease
    Fiala, Milan
    Hammock, Bruce D.
    Hwang, Sung Hee
    Whitelegge, Julian
    Paul, Ketema
    Kaczor-Urbanowicz, Karolina Elzbieta
    Urbanowicz, Andrzej
    Kesari, Santosh
    JOURNAL OF ALZHEIMERS DISEASE, 2025, 104 (01) : 150 - 157
12345