Synthesis and characterization of potential impurities of ezetimibe

被引：0

作者：

Satheesh, Deekonda ^{[1
,2
]}

Devi, Dharmasoth Rama ^{[3
]}

Basavaiah, Keloth ^{[2
]}

Sreenivasulu, B. ^{[1
]}

Reddy, Bhavanam Sekhara ^{[1
]}

Aegurla, Balakrishna ^{[1
]}

Kumar, Pallerla Satish ^{[1
]}

Guduri, Anil Kumar ^{[1
]}

Chavakula, Ramadas ^{[1
]}

机构：

[1] Aurobindo Pharma Ltd, Chem Res Dept, APL Res Ctr 2, Sangareddy 502329, Telangana, India

[2] Andhra Univ, AU Coll Sci & Technol, Dept Inorgan & Analyt Chem, Visakhapatnam, Andhra Pradesh, India

[3] Dr Sameoul George Inst Pharmaceut Sci, Markapur, India

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2023年 / 60卷 / 02期

关键词：

API; ezetimibe; des-fluoro aniline analog; ICH; m-fluoro aniline analog; o-fluorobenzene isomer; related substances; REDUCTION; MECHANISM; KETONES;

D O I：

10.1002/jhet.4584

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ezetimibe is an azetidinone derivative and a substituted beta-lactam, it is a hypolipidemic agent, and a drug substance that lowers the cholesterol levels in our body. The present work describes the origin, synthesis, and characterization of three impurities of ezetimibe, which are also positional isomers and/or related substances of ezetimibe. viz: o-Fluoro benzene isomer, m-Fluoro aniline analog, and des-fluoro aniline analogs of ezetimibe.

引用

页码：318 / 326

页数：9

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