Body composition and metabolic syndrome in patients with type 1 diabetes

被引:5
|
作者
Zeng, Qiong [1 ]
Chen, Xiao-Jing [2 ]
He, Yi-Ting [2 ]
Ma, Ze-Ming [2 ]
Wu, Yi-Xi [3 ]
Lin, Kun [3 ]
机构
[1] Shantou Univ, Affiliated Hosp 1, Dept Neurol, Med Coll, Shantou 515041, Guangdong, Peoples R China
[2] Shantou Univ, Med Coll, Shantou 515041, Guangdong, Peoples R China
[3] Shantou Univ, Med Coll, Affiliated Hosp 1, Dept Endocrinol, 57 Changping Rd, Shantou 515041, Guangdong, Peoples R China
关键词
Body composition; Metabolic syndrome; Insulin resistance; Visceral fat; Estimated glucose disposal rate; CARDIOVASCULAR-DISEASE RISK; INSULIN-RESISTANCE; WEIGHT-GAIN; COMPLICATIONS; OBESITY; FAT; AUTOIMMUNITY; ASSOCIATION; ADOLESCENTS; OVERWEIGHT;
D O I
10.4239/wjd.v15.i1.81
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BACKGROUND In recent years, the prevalence of obesity and metabolic syndrome in type 1 diabetes (T1DM) patients has gradually increased. Insulin resistance in T1DM deserves attention. It is necessary to clarify the relationship between body composition, metabolic syndrome and insulin resistance in T1DM to guide clinical treatment and intervention. AIM To assess body composition (BC) in T1DM patients and evaluate the relationship between BC, metabolic syndrome (MS), and insulin resistance in these indi-viduals. METHODS A total of 101 subjects with T1DM, aged 10 years or older, and with a disease duration of over 1 year were included. Bioelectrical impedance analysis using the Tsinghua-Tongfang BC Analyzer BCA-1B was employed to measure various BC parameters. Clinical and laboratory data were collected, and insulin resistance was calculated using the estimated glucose disposal rate (eGDR). RESULTS MS was diagnosed in 16/101 patients (15.84%), overweight in 16/101 patients (15.84%), obesity in 4/101 (3.96%), hypertension in 34/101 (33.66%%) and dyslipidemia in 16/101 patients (15.84%). Visceral fat index (VFI) and trunk fat mass were significantly and negatively correlated with eGDR (both P < 0.001). Female patients exhibited higher body fat percentage and visceral fat ratio compared to male patients. Binary logistic regression analysis revealed that significant factors for MS included eGDR [P = 0.017, odds ratio (OR) = 0.109], VFI (P = 0.030, OR = 3.529), and a family history of diabetes (P = 0.004, OR = 0.228). Significant factors for hypertension included eGDR (P < 0.001, OR = 0.488) and skeletal muscle mass (P = 0.003, OR = 1.111). Significant factors for dyslipidemia included trunk fat mass (P = 0.033, OR = 1.202) and eGDR (P = 0.037, OR = 0.708). CONCLUSION Visceral fat was found to be a superior predictor of MS compared to conventional measures such as body mass index and waist-to-hip ratio in Chinese individuals with T1DM. BC analysis, specifically identifying visceral fat (trunk fat), may play an important role in identifying the increased risk of MS in non-obese patients with T1DM.
引用
收藏
页数:12
相关论文
共 50 条
  • [31] Body composition in adolescent girls with Type 1 diabetes
    Ingberg, CM
    Särnblad, S
    Palmér, M
    Schvarcz, E
    Berne, C
    Åman, J
    DIABETIC MEDICINE, 2003, 20 (12) : 1005 - 1011
  • [32] Growth and body composition in type 1 diabetes mellitus
    Dunger, D
    Ahmed, L
    Ong, K
    HORMONE RESEARCH, 2002, 58 : 66 - 71
  • [33] BODY MASS INDEX VERSUS BODY COMPOSITION IN ASSOCIATION WITH METABOLIC DISEASES Type 2 diabetes and metabolic surgery
    Morelli, C.
    Hernandez, J.
    Morales, S.
    Pimentel, F.
    Perez, G.
    Munoz, R.
    Crovari, F.
    Quezada, N.
    OBESITY SURGERY, 2017, 27 : 1124 - 1124
  • [34] Type 1 diabetes, metabolic syndrome and cardiovascular risk
    Chillaron, Juan J.
    Flores Le-Roux, Juana A.
    Benaiges, David
    Pedro-Botet, Juan
    METABOLISM-CLINICAL AND EXPERIMENTAL, 2014, 63 (02): : 181 - 187
  • [35] The potential of the Mediterranean diet to improve metabolic control and body composition in youths with Type 1 Diabetes Mellitus
    Guenes Kaya, Didem
    Arslan, Neslihan
    Ayyildiz, Feride
    Bayramoglu, Elvan
    Turan, Hande
    Ercan, Oya
    BMC ENDOCRINE DISORDERS, 2024, 24 (01)
  • [36] Metabolic syndrome in type 1 diabetes and its association with diabetes complications
    Lee, Angela S.
    Twigg, S. M.
    Flack, J. R.
    DIABETIC MEDICINE, 2021, 38 (02)
  • [37] ASSESSMENT OF THE STATE OF THE FAT COMPONENT OF THE BODY COMPOSITION IN PATIENTS WITH TYPE 1 DIABETES MELLITUS
    Dydyshka, Y.
    Shepelkevich, A.
    Vasilyeva, N.
    Salco, O.
    Lobashova, V.
    Brutskaya-Stempkovskaya, E.
    AGING CLINICAL AND EXPERIMENTAL RESEARCH, 2023, 35 : S343 - S343
  • [38] Body Composition and Basal Metabolic Rate in Women with Type 2 Diabetes Mellitus
    Ferreira, Marina de Figueiredo
    Detrano, Filipe
    de Oliveira Coelho, Gabriela Morgado
    Barros, Maria Elisa
    Lanzillotti, Regina Serrao
    Nogueira Neto, Jose Firmino
    Portella, Emilson Souza
    Lanzillotti, Haydee Serrao
    Soares, Eliane de Abreu
    JOURNAL OF NUTRITION AND METABOLISM, 2014, 2014
  • [39] Cardiovascular Risk Factors Characteristic for the Metabolic Syndrome in Adult Patients with Type 1 Diabetes
    Nadas, J.
    Putz, Z.
    Fovenyi, J.
    Gaal, Z.
    Gyimesi, A.
    Hidvegi, T.
    Hosszufalusi, N.
    Neuwirth, G.
    Oroszlan, T.
    Panczel, P.
    Szeles, G.
    Vandorfi, G.
    Winkler, G.
    Wittmann, I.
    Jermendy, G.
    EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2009, 117 (03) : 107 - 112
  • [40] Inflammatory Cytokine Profile Associated with Metabolic Syndrome in Adult Patients with Type 1 Diabetes
    Ferreira-Hermosillo, Aldo
    Molina-Ayala, Mario
    Ramirez-Renteria, Claudia
    Vargas, Guadalupe
    Gonzalez, Baldomero
    Isibasi, Armando
    Archundia-Riveros, Irma
    Mendoza, Victoria
    JOURNAL OF DIABETES RESEARCH, 2015, 2015