Ischemia with Nonobstructive Coronary Artery Disease and Atrial Cardiomyopathy-Two Sides of the Same Story?

被引:2
|
作者
Afrasanie, Irina [1 ,2 ]
Matei, Iulian Theodor [1 ,2 ]
Leanca, Sabina Andreea [1 ,2 ]
Chetran, Adriana [1 ,2 ]
Costache, Alexandru Dan [2 ,3 ]
Afrasanie, Vlad-Adrian [4 ,5 ]
Dmour, Bianca-Ana [2 ]
Crisu, Daniela [1 ]
Badescu, Minerva Codruta [2 ,6 ]
Serban, Lacramioara Ionela [7 ]
Costache, Irina Iuliana [1 ,2 ]
机构
[1] St Spiridon Cty Clin Emergency Hosp, Cardiol Clin, Iasi 700111, Romania
[2] Grigore T Popa Univ Med & Pharm, Dept Internal Med, Iasi 700115, Romania
[3] Clin Rehabil Hosp, Dept Cardiovasc Rehabil, Iasi 700661, Romania
[4] Grigore T Popa Univ Med & Pharm, Dept Med Oncol, Iasi 700115, Romania
[5] Reg Inst Oncol, Dept Oncol, Iasi 700483, Romania
[6] St Spiridon Cty Clin Emergency Hosp, Internal Med Clin, Iasi 700111, Romania
[7] Grigore T Popa Univ Med & Pharm, Dept Physiol, Iasi 700115, Romania
来源
LIFE-BASEL | 2023年 / 13卷 / 02期
关键词
INOCA; coronary microvascular dysfunction; atrial cardiomyopathy; atrial fibrillation; heart failure; endothelial dysfunction; systemic inflammation; comorbidities; OBSTRUCTIVE SLEEP-APNEA; EPICARDIAL ADIPOSE-TISSUE; POSITIVE AIRWAY PRESSURE; TYPE-2; DIABETES-MELLITUS; VASCULAR ENDOTHELIAL FUNCTION; CONVERTING ENZYME-INHIBITION; PEPTIDE-1 ANALOG LIRAGLUTIDE; FLOW-MEDIATED DILATATION; LIPID-LOWERING THERAPY; VON-WILLEBRAND-FACTOR;
D O I
10.3390/life13020443
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Ischemia with nonobstructive coronary artery disease (INOCA) is increasingly recognized as a significant cause of angina, myocardial remodeling, and eventually heart failure (HF). Coronary microvascular dysfunction (CMD) is a major endotype of INOCA, and it is caused by structural and functional alterations of the coronary microcirculation. At the same time, atrial cardiomyopathy (ACM) defined by structural, functional, and electrical atrial remodeling has a major clinical impact due to its manifestations: atrial fibrillation (AF), atrial thrombosis, stroke, and HF symptoms. Both these pathologies share similar risk factors and have a high comorbidity burden. CMD causing INOCA and ACM frequently coexist. Thus, questions arise whether there is a potential link between these pathologies. Does CMD promote AF or the reverse? Which are the mechanisms that ultimately lead to CMD and ACM? Are both part of a systemic disease characterized by endothelial dysfunction? Lastly, which are the therapeutic strategies that can target endothelial dysfunction and improve the prognosis of patients with CMD and ACM? This review aims to address these questions by analyzing the existing body of evidence, offering further insight into the mechanisms of CMD and ACM, and discussing potential therapeutic strategies.
引用
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页数:31
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