Sulbactam-durlobactam: A Step Forward in Treating Carbapenem-Resistant Acinetobacter baumannii (CRAB) Infections

被引：8
|
作者：
Watkins, Richard R. [1 ,4 ]
Bonomo, Robert A. [2 ,3 ]
机构：
[1] Northeast Ohio Med Univ, Dept Med, Div Infect Dis, Rootstown, OH USA
[2] VA Northeast Ohio Healthcare Syst, Res Serv, Cleveland, OH USA
[3] Case Western Reserve Univ, Cleveland VA Med Ctr Antimicrobial Resistance & Ep, Cleveland, OH USA
[4] Northeast Ohio Med Univ, Dept Med, 4209 St,OH 44, Rootstown, OH 44272 USA
来源：
CLINICAL INFECTIOUS DISEASES | 2023年 / 76卷
关键词：
antimicrobial resistance; carbapenem-resistant Acinetobacter baumannii; sulbactam-durlobactam; BETA-LACTAM ANTIBIOTICS;
D O I：
10.1093/cid/ciad093
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Antimicrobial resistance in gram-negative pathogens, such as Acinetobacter baumannii, is a serious threat to human health. Sulbactam-durlobactam, a unique beta-lactam and a beta-lactamase inhibitor combination, is a novel agent targeted against carbapenem-resistant A. baumannii. This supplement provides a summary of the development of SUL-DUR, discussing its unique features and role in treating infections caused by CRAB pathogens.
引用
收藏
页码：S163 / S165
页数：3
相关论文
共 50 条
  • [21] Incidence of infections caused by carbapenem-resistant Acinetobacter baumannii
    Rossi, Iara
    Royer, Sabrina
    Ferreira, Melina Lorraine
    Campos, Paola Amaral
    Fuga, Bruna
    Melo, Gabriel Nogueira
    Machado, Luiz Gustavo
    Resende, Daiane Silva
    Batistao, Deivid
    Urzedo, Jane Eire
    Gontijo-Filho, Paulo P.
    Ribas, Rosineide Marques
    AMERICAN JOURNAL OF INFECTION CONTROL, 2019, 47 (12) : 1431 - 1435
  • [22] Treatment Approaches for Carbapenem-Resistant Acinetobacter baumannii Infections
    Iovleva, Alina
    Fowler Jr, Vance G.
    Doi, Yohei
    DRUGS, 2025, 85 (01) : 21 - 40
  • [23] Treatment of infections caused by carbapenem-resistant Acinetobacter baumannii
    Zhang, Siqin
    Di, Lingfang
    Qi, Yan
    Qian, Xiang
    Wang, Siwei
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2024, 14
  • [24] Active surveillance for carbapenem-resistant Acinetobacter baumannii (CRAB) carriage
    Nutman, Amir
    Levi, Gabrielle D.
    Keren-Paz, Alona
    Schwartz, David
    Masarwa, Samira
    Schechner, Vered
    Carmeli, Yehuda
    MICROBIOLOGY SPECTRUM, 2023,
  • [25] Evaluation of the Efficacy of Colistin/Sulbactam Combination on Carbapenem-Resistant Acinetobacter baumannii Strains
    Cetinkol, Yeliz
    Telli, Murat
    Altuncekic Yildirim, Arzu
    Calgin, Mustafa Kerem
    MIKROBIYOLOJI BULTENI, 2016, 50 (03): : 460 - 465
  • [26] Zidebactam restores sulbactam susceptibility against carbapenem-resistant Acinetobacter baumannii isolates
    Cedano, Jose
    Baez, Michelle
    Pasteran, Fernando
    Montana, Sabrina Daiana
    Ra, Grace
    Fua, Venjaminne
    Corso, Alejandra
    Tolmasky, Marcelo E.
    Bonomo, Robert A.
    Ramirez, Maria Soledad
    FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 2022, 12
  • [27] Carbapenem-resistant Acinetobacter baumannii infections after organ transplantation
    Reddy, P.
    Zembower, T. R.
    Ison, M. G.
    Baker, T. A.
    Stosor, V.
    TRANSPLANT INFECTIOUS DISEASE, 2010, 12 (01) : 87 - 93
  • [28] The Rise of Carbapenem-Resistant Acinetobacter baumannii
    Evans, Benjamin A.
    Hamouda, Ahmed
    Amyes, Sebastian G. B.
    CURRENT PHARMACEUTICAL DESIGN, 2013, 19 (02) : 223 - 238
  • [29] In Vivo Emergence of Pandrug-Resistant Acinetobacter baumannii Strain: Comprehensive Resistance Characterization and Compassionate Use of Sulbactam-Durlobactam
    VanNatta, Mollie
    Grier, Laurie
    Khan, Muhammad H.
    Cornejo, Paulette Pinargote
    Alam, Mohammad
    Moussa, Samir H.
    Smith, Jennifer G.
    Aitken, Samuel L.
    Malek, Alexandre E.
    OPEN FORUM INFECTIOUS DISEASES, 2023, 10 (10):
  • [30] Transcriptomic investigations of polymyxins and colistin/sulbactam combination against carbapenem-resistant Acinetobacter baumannii
    Bian, Xingchen
    Li, Mengyao
    Liu, Xiaofen
    Zhu, Yan
    Li, Jian
    Bergen, Phillip J.
    Li, Wanzhen
    Li, Xin
    Feng, Meiqing
    Zhang, Jing
    COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2024, 23 : 2595 - 2605
12345