The crosstalk effects of polybrominated diphenyl ethers on the retinoic acid and thyroid hormone signaling pathway

被引:6
|
作者
Zhang, Bin [1 ,2 ]
Chen, Fu [3 ]
Xu, Ting [2 ,4 ]
Tian, Yijun [1 ]
Zhang, Yajie [2 ]
Cao, Miao [2 ]
Guo, Xueping [2 ]
Yin, Daqiang [2 ,4 ]
机构
[1] Naval Med Univ, Fac Naval Med, Dept Hlth Toxicol, Shanghai 200433, Peoples R China
[2] Tongji Univ, Coll Environm Sci & Engn, Minist Educ, Key Lab Yangtze River Water Environm, Shanghai 200092, Peoples R China
[3] Shanghai Normal Univ, Sch Environm & Geog Sci, Shanghai 200234, Peoples R China
[4] Shanghai Inst Pollut Control & Ecol Secur, Shanghai 200092, Peoples R China
基金
中国国家自然科学基金; 中国博士后科学基金;
关键词
PBDEs; Endocrine disruption; Neurodevelopmental toxicity; Retinoic acid signaling pathway; VITAMIN-A; ENDOCRINE DISRUPTION; GENE-EXPRESSION; EXPOSURE; PBDES; HOMEOSTASIS; METABOLITES; MECHANISMS; RECEPTORS; INTERACT;
D O I
10.1016/j.scitotenv.2023.163590
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
The toxicological and pathological influences of polybrominated diphenyl ethers (PBDEs) on the animal central nervous system have attracted worldwide attention. However, their mechanism of action has not been completely elucidated. Given that retinoic acid (RA) and thyroid hormone (TH) signaling pathway are closely related to neurodevelopment, the crosstalk between the two signaling pathways at the levels of metabolite conversion, gene expression and ligand-receptor interaction after exposure to two representative PBDE congeners (BDE-47 and BDE-209) using zebrafish larvae, dual reporter gene assay, and docking simulation was studied. Our results clarified that BDE-47 could disrupt the transport and metabolism of retinoids, induce changes in expression of key genes, bind with the seven nuclear receptors, and activate RA signaling pathway. BDE-47 exhibited more effects on the indicators of the two signaling pathways than BDE-209. Furthermore, BDE-47 may disrupt TH signaling pathway by disrupting RA signaling pathway, indicating that RA signal is priorly influenced than TH signal. This work offered a new perspective to elucidate TH signal disruption mechanism induced by PBDEs from RA signaling pathway, which is of great significance to elucidate the health effects of PBDEs.
引用
收藏
页数:8
相关论文
共 50 条
  • [21] Hydroxylated polybrominated diphenyl ethers exhibit different activities on thyroid hormone receptors depending on their degree of bromination
    Ren, Xiao-Min
    Guo, Liang-Hong
    Gao, Yu
    Zhang, Bin-Tian
    Wan, Bin
    TOXICOLOGY AND APPLIED PHARMACOLOGY, 2013, 268 (03) : 256 - 263
  • [22] Photolytic debromination pathway of polybrominated diphenyl ethers in hexane by sunlight
    Wei, Hua
    Zou, Yonghong
    Li, An
    Christensen, Erik R.
    Rockne, Karl J.
    ENVIRONMENTAL POLLUTION, 2013, 174 : 194 - 200
  • [23] Disruption of Thyroid Hormone Receptor-Mediated Transcription and Thyroid Hormone-Induced Purkinje Cell Dendrite Arborization by Polybrominated Diphenyl Ethers
    Ibhazehiebo, Kingsley
    Iwasaki, Toshiharu
    Kimura-Kuroda, Junko
    Miyazaki, Wataru
    Shimokawa, Noriaki
    Koibuchi, Noriyuki
    ENVIRONMENTAL HEALTH PERSPECTIVES, 2011, 119 (02) : 168 - 175
  • [24] Epigenetic Effects of Polybrominated Diphenyl Ethers on Human Health
    Poston, Robert G.
    Saha, Ramendra N.
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 2019, 16 (15)
  • [25] Polybrominated diphenyl ethers (PBDEs) in grey seals during their first year of life - are they thyroid hormone endocrine disrupters?
    Hall, AJ
    Kalantzi, OI
    Thomas, GO
    ENVIRONMENTAL POLLUTION, 2003, 126 (01) : 29 - 37
  • [26] Impact of Polybrominated Diphenyl Ethers on Thyroid Hormone Levels Among California Women During Second Trimester of Pregnancy
    Zota, Ami
    Schwartz, Jackie
    Steinauer, Jody
    Petreas, Myrto
    Pasternack, Tanya
    Woodruff, Tracey
    EPIDEMIOLOGY, 2011, 22 (01) : S161 - S161
  • [27] Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and chlorinated paraffins (CPs) in rats - testing interactions and mechanisms for thyroid hormone effects
    Hallgren, S
    Darnerud, PO
    TOXICOLOGY, 2002, 177 (2-3) : 227 - 243
  • [28] The Toxic Effects of Polybrominated Diphenyl Ethers on Rotifer Branchionus plicatilis
    Zhang, Jing
    Wang, You
    Tang, Xuexi
    Fang, Kuan
    ENVIRONMENTAL PROTECTION AND RESOURCES EXPLOITATION, PTS 1-3, 2013, 807-809 : 385 - 391
  • [29] Effects of Polybrominated Diphenyl Ethers on the Steroidogenesis in Rat Leydig Cells
    Wang, Kai-Lee
    Hsia, Shih-Min
    Wang, Paulus S.
    BIOLOGY OF REPRODUCTION, 2010, : 66 - 67
  • [30] Study on the Biomolecular Competitive Mechanism of Polybrominated Diphenyl Ethers and Their Derivatives on Thyroid Hormones
    Liu, Shaoheng
    Hu, Rong
    Zhan, Hao
    You, Wanli
    Tao, Jianjun
    Jiang, Luhua
    MOLECULES, 2023, 28 (21):