Targeting WNT/β-Catenin via Modulating EZH2 Function: A New Chapter in the Treatment of β-Catenin Mutant Hepatocellular Carcinoma?

被引：1
|
作者：
Hung, Man Hsin [1 ]
Wang, Xin Wei [1 ,2 ,3 ,4 ]
机构：
[1] NCI, Ctr Canc Res, Lab Human Carcinogenesis, Bethesda, MD USA
[2] NCI, Ctr Canc Res, Liver Canc Program, Bethesda, MD USA
[3] NCI, Lab Human Carcinogenesis, Bethesda, MD 20892 USA
[4] NCI, Liver Canc Program, Bethesda, MD 20892 USA
来源：
CANCER RESEARCH | 2023年 / 83卷 / 21期
关键词：
MICE;
D O I：
10.1158/0008-5472.CAN-23-2921
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In a recent study, Rialdi and colleagues identified a specific vulnerability in beta-catenin mutant hepatocellular carcinoma (HCC) via EZH2-mediated suppression of WNT signaling and revealed the selective anti-HCC activity of WNTinib, a chemical derivative of regorafenib and sorafenib in targeting this vulnerability. Their discoveries highlight the role of EZH2 in modulating WNT signaling and suggest an implication of WNTinihb as a small-molecule inhibitor for the treatment of HCC with activated WNT/beta-catenin.
引用
收藏
页码：3498 / 3500
页数：3
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