Intra-operative tranexamic acid: A standard of care?

被引：0

作者：

Relke, Nicole ^{[1
]}

Tang, Grace H. ^{[2
,3
]}

Sholzberg, Michelle ^{[2
,3
,4
]}

机构：

[1] Univ Toronto, Dept Med, Div Hematol, Toronto, ON, Canada

[2] Univ Toronto, Dept Med, Div Hematol, Toronto, ON, Canada

[3] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, Dept Lab Med & Pathobiol, Toronto, ON, Canada

[4] Univ Toronto, St Michaels Hosp, Li Ka Shing Knowledge Inst, 30 Bond St,Room 2-007G Core Lab, Toronto, ON M5B 1W8, Canada

来源：

BEST PRACTICE & RESEARCH-CLINICAL ANAESTHESIOLOGY | 2023年 / 37卷 / 04期

关键词：

Tranexamic acid; Anti-fibrinolytic; Surgery; Intra-operative; Thrombosis; TOTAL KNEE ARTHROPLASTY; RED-BLOOD-CELL; ORTHOPEDIC-SURGERY; NONCARDIAC SURGERY; JOINT INFECTION; DOUBLE-BLIND; TRANSFUSION; APROTININ; RISK; MORTALITY;

D O I：

10.1016/j.bpa.2023.11.006

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Peri-operative bleeding is a major cause of morbidity and mortality in patients undergoing surgery. Tranexamic acid, an antifibrinolytic agent, is effective for prevention and treatment of bleeding in a variety of different surgical populations. This review summarizes the evidence supporting the use of tranexamic acid in major surgical settings including cardiac surgery, obstetrics, orthopedic surgery, and non -cardiac surgery. We discuss potential adverse effects with use of tranexamic acid including the theoretical risk of thrombosis. Lastly, we discuss other potential benefits of tranexamic acid including prevention of infection and maintenance of bloodbrain barrier

引用

页码：468 / 476

页数：9

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