Access to distal meta-C-H functionalization of arylmethanesulfonic acid derivatives

被引：4
|
作者：
Srinivas, Dasari [1 ]
Mounika, Kurella [1 ]
Satyanarayana, Gedu [1 ]
机构：
[1] Indian Inst Technol IIT, Dept Chem, Sangareddy 502284, India
来源：
CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 59期
关键词：
OLEFINATION; TEMPLATE; ACETOXYLATION; ALKENYLATION; BONDS;
D O I：
10.1039/d3cc02260a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Herein, we report the meta-C-H olefination of arylmethanesulfonates aided by a potentially versatile aliphatic nitrile-directing group under microwave irradiation conditions with fair to very good yields and good to outstanding regioselectivities. Significantly, the protocol showed broad substrate scope including olefin-derived drugs and cyclic olefins. Remarkably, a dual meta-C-H bond was amenable to generating the bis-olefination products.
引用
收藏
页码：9106 / 9109
页数：4
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