Nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes

Alkene dicarbofunctionalization is an efficient strategy and operation-economic fashion for introducing complexity in molecules. A nickel/photoredox dual catalyzed arylalkylation of nonactivated alkenes for the simultaneous construction of one C(sp3)-C(sp3) bond and one C(sp3)-C(sp2) bond has been developed. The mild catalytic method provided valuable indanethylamine derivatives with wide substrate scope and good functional group compatibility. An enantioselective dicarbofunctionalization was also achieved with pyridine-oxazoline as a ligand. The efficiency of metallaphotoredox dicarbofunctionalization was demonstrated for the concise synthesis of pharmaceutically active compounds. Dicarbofunctionalization of nonactivated alkenes is a simple way to rapidly build molecular complexity, but these transformations have not been extensively explore under metallaphotoredox conditions. Here, the authors develop a nickel/photoredox dual catalytic system for arylalkylation of alkenes.