Prognostic, diagnostic and clinicopathological roles of tsRNAs: a meta-analysis in breast cancer

被引:1
|
作者
Gao, Lu-Jue [1 ,3 ]
Zhu, Si-Xun [2 ,3 ]
Wei, Ying-Yi [1 ,3 ]
Meng, Hua-Wei [1 ,3 ]
Gu, Jing [1 ,3 ]
Zhang, Hao [1 ,3 ]
Dai, Li-Juan [1 ,3 ]
机构
[1] Taicang Hosp Tradit Chinese Med, Suzhou, Peoples R China
[2] Jiangyin Tradit Chinese Med Hosp, Jiangyin, Peoples R China
[3] Nanjing Univ Chinese Med, Nanjing, Peoples R China
关键词
Prognostic; Diagnostic; Clinicopathological; tsRNAs; Breast cancer; Meta; RNA-DERIVED FRAGMENTS; PROGRESSION; QUALITY;
D O I
10.1186/s40001-023-01617-2
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Breast cancer (BC) is one of the most common malignancies in women and the leading cause of cancer-related death in women. The newly emerged non-coding RNAs tsRNAs (tRNA-derived small RNAs) play an important role in the occurrence and development of BC. The purpose of this study was to comprehensively evaluate the prognostic, diagnostic and clinicopathological roles of tsRNAs in BC. Through literature screening, a total of 13 BC-related tsRNA studies were included in this meta-analysis, all of which passed quality assessment. Prognostic studies showed upregulated tsRNAs to be associated with poor survival outcomes (HR = 1.64, 95%CI 1.51-1.77) and downregulated tsRNAs to be associated with better outcomes (HR = 0.58, 95%CI 0.50-0.68). Results of diagnostic studies showed a combined sensitivity of 72% (95%CI 68-76%) and combined specificity of 64% (95%CI 61-67%); the AUC was 0.72 (95%CI 0.68-0.75) and the DOR 4.62 (95%CI 3.76-5.68). Finally, correlation analysis of clinicopathological features showed that downregulation of tsRNAs correlated significantly with age, TNM stage and lymphatic metastasis. Sensitivity analysis and publication bias showed no significant difference. In conclusion, BC-associated tsRNAs are closely related to the prognosis and clinicopathological features of patients with this disease and can be used to assist in early diagnosis of BC. Therefore, tsRNAs are potential targets for the diagnosis and treatment of BC.
引用
收藏
页数:13
相关论文
共 50 条
  • [1] Prognostic, diagnostic and clinicopathological roles of tsRNAs: a meta-analysis in breast cancer
    Lu-Jue Gao
    Si-Xun Zhu
    Ying-Yi Wei
    Hua-Wei Meng
    Jing Gu
    Hao Zhang
    Li-Juan Dai
    European Journal of Medical Research, 29
  • [2] Diagnostic and prognostic values of tsRNAs in lung cancer: a meta-analysis
    Tang, Cheng
    Sun, Su-Xia
    Gu, Chao
    Li, Chao-Juan
    Xu, Jin
    Su, Ke-Lei
    Zhou, Dan-Dan
    Yu, Kuai
    Xiao, Qing-Ling
    Chen, Xiao-Li
    BMC CANCER, 2025, 25 (01)
  • [3] The diagnostic and prognostic value of tsRNAs in gastric cancers: a systematic review and meta-analysis
    Gao, Hua
    Zhang, Qiankun
    Wu, Weibing
    Gu, Jing
    Li, Jia
    EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2023, 23 (11) : 985 - 997
  • [4] Prognostic and clinicopathological value of Twist expression in breast cancer: A meta-analysis
    Qiao, Weiqiang
    Jia, Zhiqiang
    Liu, Heyang
    Liu, Qipeng
    Zhang, Ting
    Quo, Wanying
    Li, Peng
    Deng, Miao
    Li, Sanqiang
    PLOS ONE, 2017, 12 (10):
  • [5] Clinicopathological and prognostic significance of GLUT1 in breast cancer A meta-analysis
    Deng, Yu
    Zou, Jialing
    Deng, Ting
    Liu, Junying
    MEDICINE, 2018, 97 (48)
  • [6] Prognostic and clinicopathological significance of microRNA-21 overexpression in breast cancer: a meta-analysis
    Pan, Fei
    Mao, Hui
    Deng, Ling
    Li, Guangchao
    Geng, Peiliang
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2014, 7 (09): : 5622 - 5633
  • [7] Clinicopathological and prognostic value of CD24 expression in breast cancer: a meta-analysis
    Liu, Gao
    Liu, Guo-Xing
    Fang, Yu
    Cao, Zhen-Yu
    Du, Hui-Hui
    Fu, Jie
    Qian, Ke
    INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS, 2017, 32 (02): : E182 - E189
  • [8] Prognostic and clinicopathological significance of cyclin B expression in patients with breast cancer A meta-analysis
    Sun, Xi
    Zhangyuan, Guangyan
    Shi, Liang
    Wang, Ying
    Sun, Beicheng
    Ding, Qiang
    MEDICINE, 2017, 96 (19)
  • [9] Clinicopathological and prognostic role of SIRT1 in breast cancer patients: a meta-analysis
    Cao, Yu-Wen
    Li, Yu-Cong
    Wan, Guo-Xing
    Du, Xiao-Ming
    Li, Feng
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2015, 8 (01): : 616 - 624
  • [10] Systematic Review With Meta-Analysis: Diagnostic, Prognostic and Clinicopathological Significance of CircRNA Expression in Renal Cancer
    Wang, Wujun
    Xie, Shengfang
    Yuan, Dongping
    He, Dandan
    Fang, Liming
    Ge, Fengfeng
    FRONTIERS IN ONCOLOGY, 2022, 11