N-SUBSTITUTED PYRIDINE SALTS WITH PHTHALIMIDE-N-OXYL ANION

Currently, various biological activities of pyridine derivatives are widely studied, the type and strength of which depends on the presence of a substituent in the molecule. The aromatic pyridine ring plays an important role in the metabolism of a living organism. It is an oxidative system, cleaving the hydride in nicotinamide adenine dinucleotide (NAD+) - a component of the dehydrogenase enzyme. Derivatives of pyridine salts are part of a variety of medicines that are used for the prevention, diagnosis and treatment of diseases of the human body as well. Therefore, we synthesized new water-soluble derivatives of N-benzylpyridinium 3-carboxamide phthalimide-N-oxyl, N-propylpyridinium 3-carboxamide phthalimide-N-oxyl and N-methylpyridinium 3-carboxamide phthalimide-N-oxyl with a pyridine ring. The reactions occurred during the interaction of the corresponding N-substituted pyridine salts of nicotinamide with various phthalimide-N-oxyl salts. Also within the framework of the work, the method of joining N-oxyphthalimide anion to N-substituted pyridine molecule was investigated, selected and developed.