Objectively-measured movement behaviors, systemic low-grade inflammation, and plasma neurofilament light chain in older adults: a population-based study

被引：1

作者：

Wang, Yongxiang ^{[1
,2
,3
,4
,5
,6
]}

Han, Qi ^{[3
,4
]}

Han, Xiaolei ^{[1
,3
,4
]}

Dong, Yi ^{[1
,3
,4
]}

Mao, Ming ^{[3
,4
]}

Wang, Chaoqun ^{[3
,4
]}

Wang, Xiaojie ^{[3
,4
]}

Tang, Shi ^{[1
,3
,4
]}

Liu, Cuicui ^{[1
,3
,4
]}

Li, Yuanjing ^{[5
,6
]}

Hou, Tingting ^{[1
,3
,4
]}

Cong, Lin ^{[1
,3
,4
]}

Du, Yifeng ^{[1
,3
,4
]}

Qiu, Chengxuan ^{[1
,5
,6
]}

机构：

[1] Shandong First Med Univ, Dept Neurol, Shandong Prov Hosp, 324,Jingwu Rd, Jinan, Shandong, Peoples R China

[2] Shandong First Med Univ & Shandong Acad Med Sci, Inst Brain Sci & Brain Inspired Res, Jinan, Shandong, Peoples R China

[3] Shandong Univ, Shandong Prov Hosp, Dept Neurol, Jinan, Shandong, Peoples R China

[4] Shandong First Med Univ, Key Lab Endocrine Glucose & Lipids Metab & Brain A, Minist Educ Peoples Republ China, Jinan, Shandong, Peoples R China

[5] Stockholm Univ, Karolinska Inst, Aging Res Ctr, Tomtebodavagen 18A, S-17165 Stockholm, Sweden

[6] Stockholm Univ, Karolinska Inst, Dept Neurobiol Care Sci & Soc, Ctr Alzheimer Res, Tomtebodavagen 18A, S-17165 Stockholm, Sweden

来源：

IMMUNITY & AGEING | 2023年 / 20卷 / 01期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

Accelerometer; Movement behaviors; Neurofilament light chain; Low-grade inflammation; Population-based study; PHYSICAL-ACTIVITY; SEDENTARY BEHAVIOR; AMYLOID-BETA; RISK; BIOMARKERS; MORTALITY; ASSOCIATIONS; PATTERNS; PREDICT; DISEASE;

D O I：

10.1186/s12979-023-00363-7

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

BackgroundEvidence has linked self-reported sedentary behavior (SB) and physical activity (PA) with cognitive impairment; however, the underlying mechanisms are poorly understood. We examined the associations of the accelerometer-measured movement behaviors with plasma neurofilament light chain (NfL) among older adults and the role of systemic low-grade inflammation in the associations.ResultsThis population-based study included 1,029 dementia-free older adults (age & GE; 60 years, range 60-88 years; 59.48% women) who undertook the ActiGraph substudy (March 2018-December 2020) in MIND-China. There were nonlinear relationships of daily SB and PA time with plasma NfL concentration, such that more daily SB time or less time spent in daily light-intensity physical activity (LPA) and moderate-to-vigorous-intensity physical activity (MVPA) was significantly associated with increased plasma NfL only when SB time & GE; 8.00 h/day or LPA time < 5.00 h/day or MVPA time < 2.00 h/day. Furthermore, more daily SB time or less daily LPA and MVPA time was significantly associated with higher serum low-grade inflammation score, a composite measure generated from serum IL-6, IL-8, TNF-& alpha;, and ICAM-1 (P < 0.05). Finally, low-grade inflammation score accounted for 14.5% to 17.8% of the associations between movement behaviors and plasma NfL.ConclusionsMore daily SB and less PA time are associated with neurodegeneration and systemic low-grade inflammation in older adults. The association of movement behaviors with neurodegeneration is partially mediated by low-grade inflammation.

引用

页数：10