Head-to-Head Comparison of FDG and Radiolabeled FAPI PET: A Systematic Review of the Literature

被引：10

作者：

Guglielmo, Priscilla ^{[1
]}

Alongi, Pierpaolo ^{[2
]}

Baratto, Lucia ^{[3
]}

Abenavoli, Elisabetta ^{[4
]}

Buschiazzo, Ambra ^{[5
]}

Celesti, Greta ^{[6
]}

Conte, Miriam ^{[7
]}

Filice, Rossella ^{[8
]}

Gorica, Joana ^{[7
]}

Jonghi-Lavarini, Lorenzo ^{[9
]}

Lanzafame, Helena ^{[10
,11
]}

Laudicella, Riccardo ^{[8
]}

Librando, Maria ^{[6
]}

Linguanti, Flavia ^{[12
]}

Mattana, Francesco ^{[13
]}

Miceli, Alberto ^{[14
]}

Olivari, Laura ^{[15
]}

Piscopo, Leandra ^{[16
]}

Romagnolo, Cinzia ^{[17
]}

Santo, Giulia ^{[18
]}

Vento, Antonio ^{[19
]}

Volpe, Fabio ^{[16
]}

Evangelista, Laura ^{[20
,21
]}

机构：

[1] Veneto Inst Oncol IOV IRCCS, I-35128 Padua, Italy

[2] ARNAS Ospedali Civ Cristina & Benfratelli, Nucl Med Unit, I-90127 Palermo, Italy

[3] Stanford Univ, Lucile Packard Childrens Hosp, Dept Radiol, Div Pediat Radiol, Stanford, CA 94304 USA

[4] Careggi Univ Hosp, Nucl Med Unit, Largo Brambilla 3, I-50134 Florence, Italy

[5] Santa Croce & Carle Hosp, Nucl Med Div, I-12100 Cuneo, Italy

[6] Univ Messina, Dept Biomed & Dent Sci & Morpho Funct Imaging, Nucl Med Unit, I-98122 Messina, Italy

[7] Sapienza Univ Rome, Dept Radiol Sci Oncol & Anatomo Pathol, I-00185 Rome, Italy

[8] Univ Palermo, Biomed Dept Internal & Specialist Med, Unit Nucl Med, I-90133 Palermo, Italy

[9] Fdn IRCCS San Gerardo Tintori, Dept Nucl Med, I-20900 Monza, Italy

[10] Univ Hosp Essen, West German Canc Ctr, Dept Nucl Med, D-45147 Essen, Germany

[11] Partner Site Univ Hosp Essen, German Canc Consortium DKTK, D-45147 Essen, Germany

[12] Univ Florence, Dept Expt & Clin Biomed Sci Mario Serio, Nucl Med Unit, I-50134 Florence, Italy

[13] IEO European Inst Oncol IRCSS, Div Nucl Med, I-20141 Milan, Italy

[14] Azienda Osped SS Antonio & Biagio & Cesare Arrigo, Nucl Med Unit, I-15121 Alessandria, Italy

[15] IRCCS Osped Sacro Cuore Don Calabria, Nucl Med Unit, I-37024 Negrar, Italy

[16] Univ Federico II, Dept Adv Biomed Sci, I-80138 Naples, Italy

[17] Ospedali Riuniti Hosp, Dept Nucl Med, I-60126 Ancona, Italy

[18] Magna Graecia Univ Catanzaro, Dept Expt & Clin Med, I-88100 Catanzaro, Italy

[19] ASP1 P O San Giovanni Dio, Nucl Med Dept, I-92100 Agrigento, Italy

[20] Humanitas Univ, Dept Biomed Sci, I-20090 Milan, Italy

[21] IRCCS Humanitas Res Hosp, I-20089 Milan, Italy

来源：

LIFE-BASEL | 2023年 / 13卷 / 09期

关键词：

fibroblast activation protein inhibitor (FAPI); FDG; PET/CT; PET/MRI; molecular imaging; hybrid imaging; new radiotracers; nuclear medicine; theranostics; FIBROBLAST ACTIVATION PROTEIN; F-18-FDG PET/CT; DIAGNOSTIC PERFORMANCE; THYROID-CANCER; NASOPHARYNGEAL CARCINOMA; PET/COMPUTED TOMOGRAPHY; EMISSION TOMOGRAPHY; GA-68-FAPI PET/CT; EXPRESSION; GUIDELINES;

D O I：

10.3390/life13091821

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

FAPI-based radiopharmaceuticals are a novel class of tracers, mainly used for PET imaging, which have demonstrated several advantages over [18F]FDG, especially in the case of low-grade or well-differentiated tumors. We conducted this systematic review to evaluate all the studies where a head-to-head comparison had been performed to explore the potential utility of FAPI tracers in clinical practice. FAPI-based radiopharmaceuticals have shown promising results globally, in particular in detecting peritoneal carcinomatosis, but studies with wider populations are needed to better understand all the advantages of these new radiopharmaceuticals.

引用

页数：27

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