CuBr-mediated synthesis of 1,4-naphthoquinones via ring expansion of 2-aryl-1,3-indandiones

被引：4

作者：

Zhang, Xu ^{[1
]}

Wang, Di ^{[1
]}

Chang, Mengfan ^{[1
]}

Wang, Wanya ^{[1
]}

Shen, Zhi ^{[1
]}

Xu, Xuefeng ^{[1
]}

机构：

[1] Nanyang Normal Univ, Coll Chem & Pharmaceut Engn, Nanyang 473061, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 82期

关键词：

C-H BONDS; ORGANOTRANSITION-METAL SYNTHESIS; CHEMOSELECTIVE ACTIVATION; CARBENE COMPLEXES; BENZANNULATION; JUGLONE; KETONES; HOMOLOGATION; DERIVATIVES; PLUMBAGIN;

D O I：

10.1039/d3cc03753c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A CuBr-mediated direct insertion of alkenes into unstrained ring 2-aryl-1,3-indandiones is reported, which provides a one-carbon ring expansion strategy for the synthesis of 1,4-naphthoquinones. Entirely differing from the existing reports, the alkenes herein behave as C1 units to participate in annulation reactions. This transformation provides a facile route to access a class of highly functionalized 1,4-naphthoquinones with good yields, good functional-group tolerance and high atom-economy. Further research on the application of this reaction is currently underway in our laboratory.

引用

页码：12326 / 12329

页数：4

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