Flavonoids from the fruits of Phyllanthus acidus (L.) Skeels with anti-α-glucosidase activity

被引：1

作者：

Xu, Jia ^{[1
,2
]}

Xin, Ying ^{[1
,2
]}

Zhu, Hong-Tao ^{[1
]}

Kong, Qing-Hua ^{[1
]}

Yang, Wei-Nong ^{[3
]}

Wang, Dong ^{[1
]}

Yang, Chong-Ren ^{[1
]}

Zhang, Ying-Jun ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming, Yunnan, Peoples R China

[2] Univ Chinese Acad Sci, Beijing, Peoples R China

[3] Yunnan Xinxing Greening Engn Co, Kunming, Yunnan, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 12期

基金：

中国国家自然科学基金;

关键词：

Phyllanthaceae; Phyllanthus acidus (L.) Skeels; flavonoids; anti-alpha-glucosidase activity; LEAVES; ANTIOXIDANT; PLANTS;

D O I：

10.1080/14786419.2022.2116704

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Eleven flavonoids including one new flavonol glycoside, quercetin-3-O-(2-alpha-L-rhamnopyranosyl)-beta-D-glucuronopyranosyl methyl ester (1), were isolated for the first time from the fruits of Phyllanthus acidus (L.) Skeels (Phyllanthaceae). Their structures were determined by extensive spectroscopic data. The known flavonoids, quercetin-3-O-beta-D-glucuronide methyl ester (3), quercetin-3-O-(2 ''-alpha-L-rhamnopyranosyl-6 ''-O-alpha-L-rhamno pyranosyl)-beta-D-glucopyranoside (5), myricetin (9), and 6-methoxy-naringenin (11) were isolated for the first time from the genus Phyllanthus. Flavonoids 4, 6 and 9 (IC50 = 6.01, 6.32, and 7.84 mu M, respectively) showed stronger alpha-glucosidase inhibitory activities than the positive control, acarbose (IC50 = 306.45 mu M). The fruits of P. acidus might be further developed as an anti-diabetic food supplement. [GRAPHICS] .

引用

页码：1986 / 1992

页数：7

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