Seroprevalence and risk factors for rubella infection in pregnant women attending a tertiary hospital in Kano-Nigeria

Introduction: rubella is a leading cause of vaccine preventable birth defects especially in developing countries. Acquisition of infection with the rubella virus in early pregnancy exposes the fetus to a very high chance of developing congenital rubella syndrome. The neonate is born with multiple abnormalities with the triad of congenital cataract, deafness and cardiovascular abnormalities like ventricular septal defect or patent ductus arteriosus. Limited data exist on the seroprevalence of rubella antibodies in pregnant women in Nigeria. The aim of this study was to determine the seroprevalence of rubella antibodies in pregnant women attending antenatal clinic in Aminu Kano Teaching Hospital, Kano State. Methods: the study was a cross-sectional study involving one hundred and sixty-three pregnant women attending antenatal clinic of Aminu Kano Teaching Hospital in Kano, Nigeria. Interviewer administered questionnaire was used to collect sociodemographic data and risk factors. Blood samples were taken from consenting pregnant women during antenatal care and samples were subjected to antibody testing (IgG and IgM). Descriptive analysis was done for sociodemographic data and seroprevalence of rubella. Chi-square tests were used to determine associations. Results: one hundred and sixty-three pregnant women were recruited for the study. The participants' age ranged from 18 to 41 years with mean age of 27.60 +/- 5.7 years. The overall rubella seroprevalence was found to be 68.7%. The seroprevalence of specific anti -Rubella virus IgM and IgG was found to be 58.4% and 37.3% respectively while prevalence of having both antiRubella virus IgG and IgM in the women was found to be 26.4%. Non -formal education and immunodeficiency was found to be associated with rubella infection (P -value of 0.018 and 0.001 respectively). Conclusion: the study found a high prevalence of anti -Rubella virus immunoglobulins in asymptomatic pregnant women attending antenatal care in our facility with immunodeficiency and non -formal education found to be significant risk factors.