Review deciphering potent therapeutic approaches targeting Notch signaling pathway in breast cancer

被引:8
|
作者
Pandey, Pratibha [1 ]
Khan, Fahad [1 ]
Choi, Min [2 ,3 ]
Singh, Sujeet Kumar [1 ]
Kang, Han Na [4 ]
Park, Moon Nyeo [2 ,3 ]
Ko, Seong-Gyu [3 ]
Sahu, Sanjeev Kumar [5 ]
Mazumder, Rupa [6 ]
Kim, Bonglee [2 ,3 ]
机构
[1] Noida Inst Engn & Technol, Dept Biotechnol, Greater Noida 201306, India
[2] Kyung Hee Univ, Coll Korean Med, Dept Pathol, Hoegidong Dongdaemun Gu, Seoul 02447, South Korea
[3] Kyung Hee Univ, Coll Korean Med, Korean Med Based Drug Repositioning Canc Res Ctr, Seoul 02447, South Korea
[4] Korea Inst Oriental Med, KM Convergence Res Div, Daejeon, South Korea
[5] Lovely Profess Univ, Sch pharmaceut Sci, Phagwara, Punjab, India
[6] Noida Inst Engn & Technol, Pharm Inst, Greater Noida 201306, India
基金
新加坡国家研究基金会;
关键词
Notch signaling pathway; Breast cancer; Natural compounds; Targeted therapeutics; Nanoparticles; DEVELOPMENTAL PATHWAYS; DOWN-REGULATION; STEM-CELLS; METASTASIS; INHIBITION; NANOPARTICLES; COMBINATION; PROGRESSION; MICRORNA; MIR-200B;
D O I
10.1016/j.biopha.2023.114938
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
In the current period of drug development, natural products have provided an unrivaled supply of anticancer medications. By modifying the cancer microenvironment and various signaling pathways, natural products and their derivatives and analogs play a significant role in cancer treatment. These substances are effective against several signaling pathways, particularly the cell death pathways (apoptosis and autophagy) and embryonic developmental pathways (Notch, Wnt, and Hedgehog pathways). Natural products have a long history, but more research is needed to understand their current function in the research and development of cancer treatments and the potential for natural products to serve as a significant source of therapeutic agents in the future. Several target-specific anticancer medications failed to treat cancer, necessitating research into natural compounds with multiple target properties. To help develop a better treatment plan for managing breast cancer, this review has outlined the anticancerous potential of several therapeutic approaches targeting the notch signaling system in breast tumors.
引用
收藏
页数:12
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