A new method to synthesize 1,2,4-oxadiazoles by using DMTMM as condensing agent

被引：4

作者：

Wang, Yijie ^{[1
]}

Cheng, Xu ^{[1
]}

Xu, Jing ^{[1
]}

Wang, Lin ^{[1
]}

Zhang, Shouguo ^{[1
]}

Liu, Shuchen ^{[1
]}

Peng, Tao ^{[1
]}

机构：

[1] Beijing Inst Radiat Med, 27 Taiping Rd, Beijing 100850, Peoples R China

来源：

TETRAHEDRON LETTERS | 2023年 / 124卷

关键词：

1; 2; 4-Oxadiazoles; Synthesis; DMTMM; INHIBITORS; DISCOVERY;

D O I：

10.1016/j.tetlet.2023.154590

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

DMTMM was used as condensing agent for synthesis of 1,2,4-oxadiazoles from corresponding carboxylic acids and amidoximes in the mixed solvent of THF and NMP. First, carboxylic acids were activated by DMTMM, and then reacted with amidoximes to convert to O-acylated amidoximes. The unusual solvent system THF-NMP successfully promoted dehydration process of O-acylated amidoximes and 1,2,4-oxa-diazoles were acquired in one-pot. This methodology provides a convenient and facile synthesis of 1,2,4-oxadiazoles with high yield.& COPY; 2023 Elsevier Ltd. All rights reserved.

引用

页数：4

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