Synthesis and structure analysis of methyl 1-benzyl-5-(phenylamino)methyl)-1H-1,2,3-triazole-4-carboxylate

Azole motifs are commonly found in the pharmaceutical industry both as in commercial products and in the literature. In particular, the triazole motifs have many applications such as drug-like and gaining attention with the development of new anticorrosive compounds have made these motifs target molecules. In the literature, it is known that amino-triazole structures have chelating, antibacterial, enzyme inhibition, anti-TB properties, and excellent anticorrosion properties. In this study, the synthesis of novel 1-benzyl-5-(phenylamino)methyl-1,2,3triazoles (5a-g) that could exhibit both drug-like interaction and corrosion inhibition properties was designed, synthesized and characterized. For this, 5a-g were obtained in one step from reactions of methyl 1-benzyl-5formyl-1H-1,2,3-triazole-4-carboxylate with anilines carrying different halogen atoms in the 2 and 4 positions. The structures of all the target molecules were fully elucidated by FT-IR, 1H NMR, 13C NMR.