Cytomegalovirus immunoglobulin therapy for CMV retinitis post hematopoietic stem cell transplantation

被引：1
|
作者：
Chiu, Tzu-Yu [1 ,2 ]
Huang, Min-Yu [1 ]
Wu, Horng-Jiun [1 ,2 ]
机构：
[1] Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Ophthalmol, Kaohsiung, Taiwan
[2] Kaohsiung Med Univ, Coll Med, Sch Med, Kaohsiung, Taiwan
来源：
EUROPEAN JOURNAL OF OPHTHALMOLOGY | 2023年 / 33卷 / 04期
关键词：
CMV retinitis; cytomegalovirus immunoglobulin; hematopoietic stem cell transplantation; RISK-FACTORS;
D O I：
10.1177/11206721221112802
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose To report a case of cytomegalovirus (CMV) retinitis complicated with ganciclovir-related myelosuppression, which was successfully managed with intravenous (IV) ganciclovir and CMV immunoglobulin (CMVIG) therapy. Methods Observational case report. Results A 51-year-old male with follicular type non-Hodgkin lymphoma post hematopoietic stem cell transplantation (HSCT) developed vision-threatening retinitis. polymerase chain reaction (PCR) of the aqueous humour showed positive for CMV. Despite myelosuppression occurred during IV ganciclovir therapy, the retinitis resolved and intraocular CMV viral load significantly improved after CMVIG therapy. Conclusion Combined IV ganciclovir treatment and CMVIG therapy can significantly improve visual outcome and reduce intraocular CMV viral load in vision-threatening CMV retinitis.
引用
收藏
页码：NP101 / NP104
页数：4
相关论文
共 50 条
  • [31] The role of immunoglobulin in hematopoietic stem cell transplantation
    Martin, A.
    Neumann, J.
    BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2007, 13 (02) : 142 - 142
  • [32] Detection of cytomegalovirus (CMV) proteins in hematopoietic stem cell transplantation (HSCT) patients by flow cytometry.
    Detrick, B
    Hooks, JJ
    Keiser, J
    Tabbara, I
    BLOOD, 1996, 88 (10) : 1687 - 1687
  • [33] Incidence and Risk Factors for Cytomegalovirus (CMV) Reactivation Following Autologous Hematopoietic Stem Cell Transplantation in Children
    Hussein, Ayad Ahmed
    Al-Antary, Eman T.
    Najjar, Rula
    Al-Hamdan, Dua'a S.
    Al-Zaben, Abdulhadi
    Frangoul, Haydar
    PEDIATRIC BLOOD & CANCER, 2015, 62 (06) : 1099 - 1101
  • [34] Cytomegalovirus (CMV) infection after hematopoietic stem cell transplantation: significant progress, but many unresolved problems
    Busca, Alessandro
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2009, 9 (04) : 383 - 385
  • [35] Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation
    Mori, T
    Mori, S
    Kanda, Y
    Yakushiji, K
    Mineishi, S
    Takaue, Y
    Gondo, H
    Harada, M
    Sakamaki, H
    Yajima, T
    Iwao, Y
    Hibi, T
    Okamoto, S
    BONE MARROW TRANSPLANTATION, 2004, 33 (04) : 431 - 434
  • [36] Clinical significance of cytomegalovirus (CMV) antigenemia in the prediction and diagnosis of CMV gastrointestinal disease after allogeneic hematopoietic stem cell transplantation
    T Mori
    S Mori
    Y Kanda
    K Yakushiji
    S Mineishi
    Y Takaue
    H Gondo
    M Harada
    H Sakamaki
    T Yajima
    Y Iwao
    T Hibi
    S Okamoto
    Bone Marrow Transplantation, 2004, 33 : 431 - 434
  • [37] The role of immunoglobulin prophylaxis for prevention of cytomegalovirus infection in pediatric hematopoietic stem cell transplantation recipients
    Goldstein, Gal
    Rutenberg, Tal Frenkel
    Mendelovich, Sarina Levy
    Hutt, Daphna
    Oikawa, Michal Teperberg
    Toren, Amos
    Bielorai, Bella
    PEDIATRIC BLOOD & CANCER, 2017, 64 (07)
  • [38] CMV Retinitis in a Stem Cell Transplant Recipient Treated with Foscarnet Intravitreal Injection and CMV Specific Immunoglobulin
    Vassallo, Francesco
    Busca, Alessandro
    Della Casa, Chiara
    Brunello, Lucia
    Giaccone, Luisa
    Butera, Sara
    Iovino, Giorgia
    De Rosa, Francesco Giuseppe
    Nuzzi, Raffaele
    Cattani, Ilaria
    Bruno, Benedetto
    BONE MARROW TRANSPLANTATION, 2020, 55 (SUPPL 1) : 507 - 507
  • [39] Intravenous Immunoglobulin Post Allogeneic Stem Cell Transplantation Is Associated with Lower Levels of CMV Reactivation
    Yannakou, Costas K.
    Robinson, Aaron J.
    Ratnasingam, Sumita
    Lim, Andrew Boon Ming
    Panek-Hudson, Yvonne
    Chau, Maggie
    Szer, Jeffrey
    Ritchie, David
    BLOOD, 2014, 124 (21)
  • [40] Cytomegalovirus reactivation following hematopoietic stem cell transplantation
    Sharma, Sanjeev Kumar
    Kumar, Suman
    Agrawal, Narendra
    Singh, Lavleen
    Mukherjee, Anjan
    Seth, Tulika
    Mishra, Pravas
    Mathur, Sandeep
    Dar, Lalit
    Mahapatra, Manoranjan
    JOURNAL OF INFECTION IN DEVELOPING COUNTRIES, 2013, 7 (12): : 1003 - 1007
12345