Efficacy of Low-Level Laser Therapy for Oral Mucositis in Hematologic Patients Undergoing Transplantation: A Single-Arm Prospective Study

被引：2

作者：

Nishi, Hiromi ^{[1
]}

Horikoshi, Susumu ^{[1
]}

Ohta, Kouji ^{[2
]}

Yoshida, Tetsumi ^{[3
]}

Fukushima, Noriyasu ^{[4
]}

Oshita, Kyoko ^{[5
]}

Munenaga, Syuichi ^{[1
]}

Edahiro, Taro ^{[3
]}

Ureshino, Hiroshi ^{[3
]}

Shigeishi, Hideo ^{[2
]}

Yoshioka, Yukio ^{[6
]}

Konishi, Masaru ^{[7
]}

Ide, Noriaki ^{[1
]}

Ogawa, Yuma ^{[8
]}

Marukawa, Rikou ^{[8
]}

Shintani, Tomoaki ^{[9
]}

Ino, Natumi ^{[10
]}

Kajiya, Mikihito ^{[9
]}

Kakimoto, Naoya ^{[11
]}

Ohge, Hiroki ^{[12
]}

Ichinohe, Tatsuo ^{[3
]}

Kawaguchi, Hiroyuki ^{[1
]}

机构：

[1] Hiroshima Univ Hosp, Dept Gen Dent, 1-2-3 Kasumi,Minami Ku, Hiroshima 7348551, Japan

[2] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Program Oral Hlth Sci, Dept Publ Oral Hlth, Hiroshima 7348551, Japan

[3] Hiroshima Univ, Res Inst Radiat Biol & Med, Dept Hematol & Oncol, Hiroshima 7348551, Japan

[4] Karatsu Red Cross Hosp, Dept Internal Med, Karatsu 8478588, Japan

[5] Hiroshima Gen Hosp, Dept Anesthesiol, Hiroshima 7348551, Japan

[6] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Oral Oncol, Hiroshima 7348551, Japan

[7] Hiroshima Univ Hosp, Dept Oral & Maxillofacial Radiol, Hiroshima 7348551, Japan

[8] Hiroshima Univ, Sch Dent, Dept Program Dent, Hiroshima 7348551, Japan

[9] Hiroshima Univ Hosp, Ctr Oral Clin Examinat, Hiroshima 7348551, Japan

[10] Hiroshima Univ Hosp, Dept Clin Practice & Support, Hiroshima 7348551, Japan

[11] Hiroshima Univ, Grad Sch Biomed & Hlth Sci, Dept Oral & Maxillofacial Radiol, Hiroshima 7348553, Japan

[12] Hiroshima Univ Hosp, Dept Infect Dis, Hiroshima 7348551, Japan

来源：

JOURNAL OF PERSONALIZED MEDICINE | 2023年 / 13卷 / 11期

关键词：

oral mucositis; hematopoietic stem cell transplantation; low-level light therapy; quality of life; Japan; STEM-CELL TRANSPLANTATION; CANCER-PATIENTS; FLUDARABINE; MELPHALAN; BUSULFAN; OUTCOMES; RISK; HEAD;

D O I：

10.3390/jpm13111603

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Oral mucositis significantly affects the quality of life in hematologic cancer patients undergoing hematopoietic stem cell transplantation. Despite global evidence supporting the efficacy of low-level laser therapy (LLLT) for mucositis prevention, its clinical adoption in Japan is limited. This study aimed to fill this gap by evaluating the safety and efficacy of LLLT in a Japanese patient population. In a single-group, non-blinded, exploratory trial, we compared 21 LLLT-treated patients against a historical control of 96 patients. The primary endpoint was the incidence of Grade >= 2 mucositis, based on NCI-CTCAE ver. 4.0. The LLLT group showed a significantly lower incidence of Grade >= 2 mucositis (23.8%) compared to the control group (64.6%) (p = 0.0006). Furthermore, Grade >= 2 mucositis correlated with increased oral dryness and longer hospital stays. Our study confirms the efficacy of LLLT in reducing the onset of severe oral mucositis among Japanese hematologic cancer patients, advocating for its clinical introduction as a preventive measure in Japan.

引用

页数：13

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