Zinc Ameliorates Tripterygium Glycosides-Induced Reproductive Impairment in Male Rats by Regulating Zinc Homeostasis and Expression of Oxidative Stress-Related Genes

被引：5
|
作者：
Ma, Jing [1 ]
Tan, He [2 ,3 ]
Bi, Jiajie [4 ]
Sun, Bo [3 ]
Zhen, Yingxian [1 ]
Lian, Weiguang [5 ]
Wang, Shusong [1 ,3 ,4 ]
机构：
[1] Hebei Reprod Hlth Hosp, Hebei Key Lab Reprod Med, 80 Heping St, Shijiazhuang 050071, Peoples R China
[2] Hebei Gen Hosp, Shijiazhuang 050051, Peoples R China
[3] Hebei Med Univ, Grad Sch, Shijiazhuang 050017, Peoples R China
[4] Chengde Med Univ, Grad Sch, Chengde 067000, Peoples R China
[5] Hebei Med Univ, Dept Lab Anim, Key Lab Hebei Prov Lab Anim, Shijiazhuang 050017, Peoples R China
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 2024年 / 202卷 / 05期
关键词：
Zinc homeostasis; Testosterone; Oxidative stress; Tripterygium glycosides; Reproductive impairment; TESTOSTERONE SYNTHESIS; EPIDIDYMAL DAMAGE; DIABETIC-RAT; LIVER-INJURY; SUPPLEMENTATION; DIETARY; MICE; DISEASE; ENZYMES; IMPACT;
D O I：
10.1007/s12011-023-03815-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Tripterygium glycosides (TG) can seriously damage male reproductive function, and the reproductive system is difficult to restore after stopping the administration of TG in male rats. Zinc (Zn) is one of the most important trace elements in the human body and plays an important role in maintaining male fertility. The aim of this study was to investigate whether zinc supplementation could improve the testicular reproductive damage induced by TG toxicity in rats and to investigate its mechanism of action. The results showed that zinc sulfate (ZnSO4) could improve testicular tissue structure and semen parameters, promote testosterone synthesis, increase zinc-containing enzyme activity, increase zinc concentration in serum and testicular tissues, and maintain zinc homeostasis in male rats induced by TG toxicity. Zinc supplementation activated relevant signalling molecules in the KEAP1-NRF2/ARE pathway and alleviated TG-induced oxidative stress. Therefore, this study concluded that zinc supplementation could improve reproductive damage by regulating zinc homeostasis and the expression of genes related to oxidative stress.
引用
收藏
页码：2111 / 2123
页数：13
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