Base-promoted tandem synthesis of 2-azaaryl indoline

被引：0

作者：

Chen, Shuguang ^{[1
]}

Tan, Jiahong ^{[1
]}

Wu, Hao ^{[1
]}

Zhao, Quansheng ^{[1
]}

Shang, Yongjia ^{[1
]}

机构：

[1] Anhui Normal Univ, Coll Chem & Mat Sci, Key Lab Funct Mol Solids, Anhui Lab Mol Based Mat,Minist Educ,State Key Lab, Wuhu 241000, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2023年 / 21卷 / 46期

基金：

中国国家自然科学基金;

关键词：

DERIVATIVES; ANTIOXIDANT; ANTICANCER; LIGANDS; DESIGN;

D O I：

10.1039/d3ob01444d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel tandem method to synthesize 2-azaaryl indoline promoted by LiN(SiMe3)2 from 2-azaaryl methyl amine and 2-fluoro benzyl bromides was developed. Mechanistic investigation indicated that this tandem cyclization was initiated by selective benzyl C-SN2 substitution followed by an intramolecular SNAr reaction. Diverse 2-azaaryl indoles could also be obtained via simple functional transformations. A novel strategy involving base-promoted tandem SN2 substitution and intramolecular SNAr addition from 2-azaaryl methyl amine and ortho-fluoro benzyl bromide was designed.

引用

页码：9133 / 9137

页数：5

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