Novel sulfonamide-functionalized arylidene indolones as potent a-glucosidase inhibitors: synthesis, characterization, and in vitro and in silico studies

被引：1
|
作者：
Nguyen, Giang V. [1 ]
Dang, Hoang T. [1 ]
Nguyen, Luyen D. [1 ]
Nguyen, Hai V. [1 ]
Le, Huong T. [1 ]
Nguyen, Huy H. N. [2 ]
Nguyen, An V. [2 ]
Nguyen, Yen H. [3 ]
Nguyen, Van-Ha [3 ]
Do, Huy-Hoang [3 ]
机构：
[1] Hanoi Univ Pharm, Hanoi 11021, Vietnam
[2] Nguyen Gia Thieu High Sch, Hanoi 11811, Vietnam
[3] Vietnam Natl Univ, Univ Sci, Fac Chem, Hanoi 11021, Vietnam
来源：
MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 04期
关键词：
indolones; arylidene indolones; sulfonamides; inhibitor; ALPHA-GLUCOSIDASE; SACCHAROMYCES-CEREVISIAE; ANTIMICROBIAL ACTIVITY; OXINDOLE DERIVATIVES; ANALOGS;
D O I：
10.1016/j.mencom.2023.06.033
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
3-Arylidene-1-(2,6-dichlorophenyl)indolones and in particular their 5-methylaminosulfonyl derivatives efficiently inhibit a-glucosidase enzyme. The results are corroborated by in silico docking studies which show the binding of aminosulfonyl derivatives to be more favorable due to additional hydrogen bonding. The most active compound of the series shows the IC50 of 6.19 & mu;M.
引用
收藏
页码：543 / 545
页数：3
相关论文
共 50 条
  • [21] Synthesis of novel coumarin-hydrazone hybrids as a-glucosidase inhibitors and their molecular docking studies
    Tariq, Hafiza Zara
    Saeed, Aamer
    Ullah, Saeed
    Fatima, Noor
    Halim, Sobia Ahsan
    Khan, Ajmal
    El-Seedi, Hesham R.
    Ashraf, Muhammad Zaman
    Latif, Muhammad
    Al-Harrasi, Ahmed
    RSC ADVANCES, 2023, 13 (37) : 26229 - 26238
  • [22] Synthesis and biological evaluation of novel coumarin derivatives bearing sulfonamide moiety as potent α-glucosidase inhibitors
    Alsukor, Alim
    Inayatsyah, Nurul Alam
    Ridhwan, Mohamad Jemain Mohamad
    Kasim, Noraini
    Imran, Syahrul
    JOURNAL OF THE IRANIAN CHEMICAL SOCIETY, 2025, 22 (01) : 207 - 217
  • [23] Dicyanoanilines as potential and dual inhibitors of α-amylase and α-glucosidase enzymes: Synthesis, characterization, in vitro, in silico, and kinetics studies
    Saleem, Faiza
    Kanwal
    Khan, Khalid Mohammed
    Chigurupati, Sridevi
    Andriani, Yosie
    Solangi, Mehwish
    Hameed, Shehryar
    Hafez, Atef Abdel Monem Abdel
    Begum, Farida
    Lodhi, Muhammad Arif
    Taha, Muhammad
    Rahim, Fazal
    Muhammad, Tengku Sifzizul bin Tengku
    Perveen, Shahnaz
    ARABIAN JOURNAL OF CHEMISTRY, 2022, 15 (03)
  • [24] Synthesis, molecular docking and ADMET studies of bis-benzimidazole-based thiadiazole derivatives as potent inhibitors, in vitro a-amylase and a-glucosidase
    Khan, Shoaib
    Iqbal, Shahid
    Rehman, Wajid
    Hussain, Nadia
    Hussain, Rafaqat
    Shah, Mazloom
    Ali, Farhan
    Fouda, Ahmed M.
    Khan, Yousaf
    Dera, Ayed A.
    Alahmdi, Mohammed Issa
    Bahadur, Ali
    Al-ghulikah, Hanan A.
    Elkaeed, Eslam B.
    ARABIAN JOURNAL OF CHEMISTRY, 2023, 16 (07)
  • [25] Novel phenylurea-pyridinium derivatives as potent urease inhibitors: Synthesis, in vitro, and in silico studies
    Sadat-Ebrahimi, Seyed Esmaeil
    Bigdelou, Azadeh
    Sooreshjani, Rasool Hassanzadeh
    Montazer, Mohammad Nazari
    Zomorodian, Kamiar
    Irajie, Cambyz
    Yahya-Meymandi, Azadeh
    Biglar, Mahmood
    Larijani, Bagher
    Amanlou, Massoud
    Iraji, Aida
    Mahdavi, Mohammad
    JOURNAL OF MOLECULAR STRUCTURE, 2022, 1263
  • [26] Novel phenylurea-pyridinium derivatives as potent urease inhibitors: Synthesis, in vitro, and in silico studies
    Sadat-Ebrahimi, Seyed Esmaeil
    Bigdelou, Azadeh
    Sooreshjani, Rasool Hassanzadeh
    Montazer, Mohammad Nazari
    Zomorodian, Kamiar
    Irajie, Cambyz
    Yahya-Meymandi, Azadeh
    Biglar, Mahmood
    Larijani, Bagher
    Amanlou, Massoud
    Iraji, Aida
    Mahdavi, Mohammad
    Journal of Molecular Structure, 2022, 1263
  • [27] Synthesis of Chalcones as Potential α-Glucosidase Inhibitors, In-Vitro and In-Silico Studies
    Mukhtar, Asma
    Shah, Shazia
    Kanwal
    Khan, Khalid Mohammed
    Khan, Shahid Ullah
    Zaib, Sumera
    Iqbal, Jamshed
    Parveen, Shahnaz
    Taha, Muhammad
    Hussain, Shafqat
    Hameed, Shahryar
    Khan, Naveed Ahmed
    Siddiqui, Ruqaiyyah
    Anwar, Ayaz
    CHEMISTRYSELECT, 2021, 6 (37): : 9933 - 9940
  • [28] Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies
    Ali, Mahboob
    Khan, Momin
    Zaman, Khair
    Wadood, Abdul
    Iqbal, Maryam
    Alam, Aftab
    Shah, Sana
    Rehman, Ashfaq Ur
    Yousaf, Muhammad
    Rafique, Rafaila
    Khan, Khalid Mohammed
    MEDICINAL CHEMISTRY, 2021, 17 (08) : 903 - 912
  • [29] Novel naphthoquinones as potent aromatase inhibitors: Synthesis, anticancer, and in silico studies
    Leechaisit, Ronnakorn
    Mahalapbutr, Panupong
    Suriya, Utid
    Prachayasittikul, Veda
    Prachayasittikul, Supaluk
    Ruchirawat, Somsak
    Prachayasittikul, Virapong
    Pingaew, Ratchanok
    JOURNAL OF MOLECULAR STRUCTURE, 2024, 1316
  • [30] Design, synthesis, in vitro and in silico studies of naproxen derivatives as dual lipoxygenase and α-glucosidase inhibitors
    Sardar, Asma
    Abid, Obaid-ur-Rahman
    Daud, Saima
    Fakhar-E-Alam, M.
    Siddique, Muhammad Hussnain
    Ashraf, Muhammad
    Shahid, Wardah
    Ejaz, Syeda Abida
    Atif, M.
    Ahmad, Shafiq
    Shafeeq, Sulman
    Afzal, Muhammad
    JOURNAL OF SAUDI CHEMICAL SOCIETY, 2022, 26 (03)
12345