FEATURES OF (BENZO)IMIDAZO[2,1-B][1,3]THIAZINE MEZYLATES REACTION WITH NUCLEOPHILIC REAGENTS

被引：0

作者：

Slyvka, Nataliia ^{[1
]}

Saliyeva, Lesya ^{[1
]}

Litvinchuk, Mariia ^{[2
]}

Shishkina, Svitlana ^{[3
]}

Vovk, Mykhailo ^{[2
]}

机构：

[1] Lesya Ukrainka Volyn Natl Univ, Dept Organ Chem & Pharm, Volya Ave 13, UA-43025 Lutsk, Ukraine

[2] Natl Acad Sci Ukraine, Inst Organ Chem, Dept Funct Heterocycl Syst, Acad Kuharya St, UA-02660 Kiev, Ukraine

[3] Natl Acad Sci Ukraine, SSI Inst Single Crystals, Dept Xray Diffract Study & Quantum Chem, Nauka Ave 60, UA-61000 Kharkiv, Ukraine

来源：

CHEMISTRY & CHEMICAL TECHNOLOGY | 2023年 / 17卷 / 03期

关键词：

nucleo-philic substitution reaction; elimination reaction; thio (isothio)cyanato and azido derivatives; (benzo)imidazo[2,1-b][1,3]thiazines; ANALOGS;

D O I：

10.23939/chcht17.03.542

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Peculiarities of the course of the methanesulfoderivatives of (benzo)imidazo[2,1-b][1,3]thiazines reactions with a number of nucleophilic reagents were studied. It was determined that they react nonselectively with potassium thiocyanate to form a mixture of thio-and isothiocyanate derivatives. When interacting with sodium azide, nucleophilic substitution competes with an elimina-tion reaction. The latter is dominant in the reaction with sodium cyanide. The spatial structure of one of the isomer elimination products, 4H-benzo[4,5]imidazo[2,1-b][1,3] thiazine, was established by X-ray structural analysis.

引用

页码：542 / 548

页数：7

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