Theophylline Hydrogen Sulfate: A green and efficient catalyst for synthesis of 3,3-bis(1H-indol-3-yl)indolin-2-one derivatives

被引：6

作者：

Pund, Ganesh B. ^{[1
]}

Wahul, Diksha B. ^{[2
]}

Deshmukh, Tejshri R. ^{[3
]}

Dhumal, Sambhaji T. ^{[4
]}

Mandave, Krishna R. ^{[5
]}

Gaware, Sujeet A. ^{[6
]}

Farooqui, Mazahar ^{[5
]}

Dobhal, Bhagwansing S. ^{[7
]}

Hebade, Madhav J. ^{[7
,8
]}

机构：

[1] Dr Rafiq Zakariya Coll Women, Dept Chem, Aurangabad, India

[2] MSSS Arts Sci & Commerce Coll Ambad, Dept Chem, Ambad, India

[3] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad, India

[4] Ramkrishna Paramhansa Mahavidyalaya, Dept Chem, Osmanabad, India

[5] Maulana Azad Coll Arts Sci & Commerce, Dept Chem, Aurangabad, India

[6] IIT Kharagpur Extens Ctr, Inst Chem Technol Indian Oil Odisha, Dept Chem, Bhubaneswar, India

[7] Badrinarayan Barwale Mahavidyalaya, Dept Chem, Jalna, India

[8] Badrinarayan Barwale Mahavidyalaya, Dept Chem, Jalna 431213, India

来源：

SYNTHETIC COMMUNICATIONS | 2023年 / 53卷 / 13期

关键词：

3; 3-Bis(1H-indol-3-yl)indolin-2-one; eco-friendly; indole; isatin; Theophylline Hydrogen Sulfate; IN-VITRO EVALUATION; ONE-POT SYNTHESIS; FACILE SYNTHESIS; ACID; INDOLES; ISATIN; 3,3'-DIINDOLYLMETHANE; CONDENSATION; MOIETY;

D O I：

10.1080/00397911.2023.2205594

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new green protocol for the synthesis of 3,3-bis(1H-indol-3-yl)indolin-2-one derivatives by reacting isatin with indole in the presence of Theophylline Hydrogen Sulfate as a new solid acid, a highly effective and reusable catalyst. This reaction was carried out by using aqueous ethanol as a solvent system at room temperature with constant stirring. A highly effective solid acid catalyst, short reaction time, better to excellent yields of the products, safe and environmentally benign reaction conditions are some of the benefits of the present synthetic method.

引用

页码：1008 / 1019

页数：12

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