Corn Silk Flavonoids Ameliorate Hyperuricemia via PI3K/AKT/NF-κB Pathway

被引：16
|
作者：
Wang, Xizhu [1 ,2 ]
Dong, Liu [1 ,2 ]
Dong, Yifei [1 ,2 ]
Bao, Zhijie [1 ,2 ]
Lin, Songyi [1 ,2 ]
机构：
[1] Dalian Polytech Univ, Natl Engn Res Ctr Seafood, Sch Food Sci & Technol, Dalian 116034, Peoples R China
[2] Dalian Polytech Univ, Liaoning Engn Res Ctr Special Dietary Food, Dalian 116034, Peoples R China
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2023年 / 71卷 / 24期
关键词：
corn silk flavonoids; xanthine oxidase; uricacid; hyperuricemia; PI3K; AKT; NF-kappa B; XANTHINE-OXIDASE; URIC-ACID; IMPROVES HYPERURICEMIA; URATE TRANSPORTERS; OXIDATIVE STRESS; WEB SERVER; PREDICTION; EXCRETION;
D O I：
10.1021/acs.jafc.3c03422
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
Hyperuricemia (HUA) is a widespread metabolic disease marked by an elevated level of uric acid, and is a risk factor for premature death. The protective effect of corn silk flavonoids (CSF) against HUA and its potential mechanisms were explored. Five important apoptosis and inflammation-related signaling pathways were identified by network pharmacological analysis. The CSF exhibited significant uric acid (UA)-lowering activity in vitro by decreasing xanthine oxidase (XOD) and increasing hypoxanthine-guanine phosphoribosyl transferase levels. In a potassium oxonate-induced HUA in vivo, CSF treatment effectively inhibited XOD activity and promoted UA excretion. Furthermore, it decreased the levels of TNF-a and IL-6 and restored pathological damage. In summary, CSF is a functional food component to improve HUA by reducing inflammation and apoptosis through the down-regulating PI3K/AKT/NF-?B pathway.
引用
收藏
页码：9429 / 9440
页数：12
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