Recurrence of primary acquired melanosis and conjunctival intraepithelial neoplasia.

IntroductionThe aim of this study was to investigate the frequency of recurrences, time to recurrence and which patients had a recurrence after treatment of conjunctival intraepithelial neoplasia (CIN), carcinoma in situ, and primary acquired melanosis (PAM) with atypia.MethodsA retrospective chart review of all patients included in the follow up program after completion of treatment for CIN or PAM with atypia on October 18, 2021, at the Department of Ophthalmology, Sahlgrenska University Hospital, was conducted.ResultsThere were five recurrences (5/31, 17%) in the group with CIN or carcinoma in situ. Two for patients with CIN grade II, and three for individuals with carcinoma in situ. Time to diagnosis of recurrence ranged from 6 to 288 months. No recurrence was diagnosed for the twenty-six patients followed after treatment for PAM with atypia.ConclusionWith the strategy of radical treatment of CIN and PAM with atypia whenever possible subsequent follow up can probably be ceased after ten years if the patient is not immunocompromised. For completely excised PAM with atypia grade I there is most likely no need for further clinical controls.