Cytotoxic steroidal glycosides from the rhizomes of Paris polyphylla var. yunnanensis

被引：10
|
作者：
Liu, Yang [1 ]
Liu, Mei-You [2 ]
Bi, Lin-Lin [3 ]
Tian, Yun-Yuan [3 ]
Qiu, Peng-Cheng [3 ]
Qian, Xiao-Ying [4 ]
Wang, Min-Chang [5 ]
Tang, Hai-Feng [3 ,7 ]
Lu, Yun-Yang [3 ]
Zhang, Bang-Le [1 ,6 ]
机构：
[1] Air Force Med Univ, Sch Pharm, Dept Pharmaceut, Xian, Peoples R China
[2] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, Xian, Peoples R China
[3] Air Force Med Univ, Sch Pharm, Dept Chinese Mat Med & Nat Med, xian, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Inst Interdisciplinary Integrat Med Res, Ctr Chem Biol, Shanghai, Peoples R China
[5] Xian Modern Chem Res Inst, Xian, Peoples R China
[6] Air Force Med Univ, Sch Pharm, Dept Pharmaceut, 169 Changle West Rd, Xian 710032, Peoples R China
[7] Air Force Med Univ, Sch Pharm, Dept Chinese Mat Med & Nat Med, 169 Changle West Rd, Xian 710032, Peoples R China
来源：
PHYTOCHEMISTRY | 2023年 / 207卷
基金：
中国国家自然科学基金;
关键词：
Paris polyphylla var; yunnanensis (Franch; Hand; -Mazz; Melanthiaceae; Saponins; Spirostane saponin; Furostanol saponins; Cytotoxicity; Apoptosis; Pyroptosis; FUROSTANOL SAPONINS; PYROPTOSIS;
D O I：
10.1016/j.phytochem.2022.113577
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Paris polyphylla var. yunnanensis (Franch.) Hand.-Mazz. (Melanthiaceae), an important specie of the genus Paris, has long been in a traditional Chinese medicine (TCM) for a long time. This study aimed to isolate and identify the structures of bioactive saponins from the rhizomes of P. polyphylla var. yunnanensis and evaluate their cytotoxicity against BxPC-3, HepG2, U373 and SGC-7901 carcinoma cell lines. Seven previously undescribed and seven known saponins were identified, and Paris saponins VII (PSVII) showed significant cytotoxicity against the BxPC-3 cell line with IC50 values of 3.59 mu M. Furthermore, flow cytometry, transmission electron microscopy and western-bolt analysis revealed that PSVII inhibited the proliferation of BxPC-3 cells and might be involved in inducing apoptosis and pyroptosis by activating caspase-3,-7 and caspase-1, respectively.
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页数：14
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