Inhibitor of apoptosis proteins as therapeutic targets in bladder cancer

被引：6
|
作者：
Wolf, Philipp [1 ,2 ]
机构：
[1] Univ Freiburg, Med Ctr, Dept Urol, Freiburg, Germany
[2] Univ Freiburg, Fac Med, Freiburg, Germany
来源：
FRONTIERS IN ONCOLOGY | 2023年 / 13卷
关键词：
bladder cancer; apoptosis; inhibitor of apoptosis proteins; cIAP1; cIAP2; XIAP; Survivin; Livin; EARLY RECURRENCE; PROGNOSTIC-SIGNIFICANCE; URINARY BIOMARKERS; MELANOMA INHIBITOR; LIGASE ACTIVITY; SMAC MIMETICS; IAP PROTEINS; SURVIVIN; EXPRESSION; LIVIN;
D O I：
10.3389/fonc.2023.1124600
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Evasion from apoptosis is a hallmark of cancer. Inhibitor of apoptosis proteins (IAPs) contribute to this hallmark by suppressing the induction of cell death. IAPs were found to be overexpressed in cancerous tissues and to contribute to therapeutic resistance. The present review focuses on the IAP members cIAP1, cIAP2, XIAP, Survivin and Livin and their importance as potential therapeutic targets in bladder cancer.
引用
收藏
页数：8
相关论文
共 50 条
  • [41] RNA-binding proteins as therapeutic targets in cancer
    Jungfleisch, Jennifer
    Gebauer, Fatima
    RNA BIOLOGY, 2025, 22 (01) : 1 - 8
  • [42] Inhibitor of apoptosis proteins and apoptosis
    Wei, Yunbo
    Fan, Tingjun
    Yu, Miaomiao
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2008, 40 (04) : 278 - 288
  • [43] Epigenetics of Bladder Cancer: Where Biomarkers and Therapeutic Targets Meet
    Martinez, Victor G.
    Munera-Maravilla, Ester
    Bernardini, Alejandra
    Rubio, Carolina
    Suarez-Cabrera, Cristian
    Segovia, Cristina
    Lodewijk, Iris
    Duenas, Marta
    Martinez-Fernandez, Monica
    Maria Paramio, Jesus
    FRONTIERS IN GENETICS, 2019, 10
  • [44] Molecular Pathways: Targeting Inhibitor of Apoptosis Proteins in Cancer-From Molecular Mechanism to Therapeutic Application
    Fulda, Simone
    CLINICAL CANCER RESEARCH, 2014, 20 (02) : 289 - 295
  • [45] Prognostic Significance of Inhibitor of Apoptosis Proteins in Gallbladder Cancer
    Chandra, Abhijit
    Nigam, Jaya
    Rajan, Pritheesh
    Gupta, Vivek
    Rajashekhara, Mahesh
    Patel, Ravi
    Sangal, Bharat
    JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2021, 233 (05) : E113 - E113
  • [46] Targeting inhibitor of apoptosis proteins (IAPs) for cancer therapy
    Fulda, Simone
    ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2008, 8 (05) : 533 - 539
  • [47] Elevated expression of inhibitor of apoptosis proteins in prostate cancer
    Krajewska, M
    Krajewski, S
    Banares, S
    Huang, XS
    Turner, B
    Bubendorf, L
    Kallioniemi, OP
    Shabaik, A
    Vitiello, A
    Peehl, D
    Gao, GJ
    Reed, JC
    CLINICAL CANCER RESEARCH, 2003, 9 (13) : 4914 - 4925
  • [48] Inhibitor of apoptosis proteins
    不详
    NATURE REVIEWS DRUG DISCOVERY, 2012, 11 (02) : 99 - 99
  • [49] TRIM proteins in lung cancer: Mechanisms, biomarkers and therapeutic targets
    Zhan, Weihua
    Zhang, Song
    LIFE SCIENCES, 2021, 268
  • [50] Proteins of the Hedgehog signaling pathway as therapeutic targets against cancer
    Nehme, Rony
    Mus-Veteau, Isabelle
    EXPERT REVIEW OF PROTEOMICS, 2010, 7 (04) : 601 - 612
12345