Retrospective Analysis of Vaccinated and Unvaccinated COVID-19 Patients Treated with Monoclonal Antibodies (mAb) and Their Emergent Needs (RAVEN)

被引:2
|
作者
Simeunovic, Gordana [1 ,2 ,3 ]
Polega, James [3 ,4 ]
Toor, Subhan [3 ,5 ]
Andersen, Nicholas J. [6 ]
机构
[1] Spectrum Hlth, Community Response Dept, Grand Rapids, MI 49503 USA
[2] Spectrum Hlth, Dept Infect Dis, Grand Rapids, MI 49503 USA
[3] Michigan State Univ, Coll Human Med, Grand Rapids, MI 49503 USA
[4] Michigan State Univ, Spectrum Hlth, Infect Dis Fellowship, Grand Rapids, MI 49503 USA
[5] Michigan State Univ, Spectrum Hlth, Internal Med Residency, Grand Rapids, MI 49503 USA
[6] Spectrum Hlth, Off Res & Educ, Grand Rapids, MI 49503 USA
关键词
COVID-19; monoclonal antibody; vaccine; PROPENSITY SCORE; REGRESSION; RISK;
D O I
10.3390/vaccines11030688
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Strategies to combat COVID-19 include vaccines and Monoclonal Antibody Therapy. While vaccines aim to prevent development of symptoms, Monoclonal Antibody Therapy aims to prevent the progression of mild to severe disease. An increasing number of COVID-19 infections in vaccinated patients raised the question of whether vaccinated and unvaccinated COVID-19 positive patients respond differently to Monoclonal Antibody Therapy. The answer can help prioritize patients if resources are scarce. We performed a retrospective study to evaluate and compare the outcomes and risks for disease progression between vaccinated and unvaccinated COVID-19 patients treated with Monoclonal Antibody Therapy by measuring the number of Emergency Department visits and hospitalizations within 14 days as well as the progression to severe disease, defined through the Intensive Care Unit admissions within 14 days, and death within 28 days from the Monoclonal Antibody infusion. From 3898 included patients, 2009 (51.5%) were unvaccinated at the time of Monoclonal Antibody infusion. Unvaccinated patients had more Emergency Department visits (217 vs. 79, p < 0.0001), hospitalizations (116 vs. 38, p < 0.0001), and progression to severe disease (25 vs. 19, p = 0.016) following treatment with Monoclonal Antibody Therapy. After adjustment for demographics and comorbidities, unvaccinated patients were 2.45 times more likely to seek help in the Emergency Department and 2.70 times more likely to be hospitalized. Our data suggest the added benefit between the COVID-19 vaccine and Monoclonal Antibody Therapy.
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页数:10
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