Retrospective Analysis of Vaccinated and Unvaccinated COVID-19 Patients Treated with Monoclonal Antibodies (mAb) and Their Emergent Needs (RAVEN)

被引:2
|
作者
Simeunovic, Gordana [1 ,2 ,3 ]
Polega, James [3 ,4 ]
Toor, Subhan [3 ,5 ]
Andersen, Nicholas J. [6 ]
机构
[1] Spectrum Hlth, Community Response Dept, Grand Rapids, MI 49503 USA
[2] Spectrum Hlth, Dept Infect Dis, Grand Rapids, MI 49503 USA
[3] Michigan State Univ, Coll Human Med, Grand Rapids, MI 49503 USA
[4] Michigan State Univ, Spectrum Hlth, Infect Dis Fellowship, Grand Rapids, MI 49503 USA
[5] Michigan State Univ, Spectrum Hlth, Internal Med Residency, Grand Rapids, MI 49503 USA
[6] Spectrum Hlth, Off Res & Educ, Grand Rapids, MI 49503 USA
关键词
COVID-19; monoclonal antibody; vaccine; PROPENSITY SCORE; REGRESSION; RISK;
D O I
10.3390/vaccines11030688
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Strategies to combat COVID-19 include vaccines and Monoclonal Antibody Therapy. While vaccines aim to prevent development of symptoms, Monoclonal Antibody Therapy aims to prevent the progression of mild to severe disease. An increasing number of COVID-19 infections in vaccinated patients raised the question of whether vaccinated and unvaccinated COVID-19 positive patients respond differently to Monoclonal Antibody Therapy. The answer can help prioritize patients if resources are scarce. We performed a retrospective study to evaluate and compare the outcomes and risks for disease progression between vaccinated and unvaccinated COVID-19 patients treated with Monoclonal Antibody Therapy by measuring the number of Emergency Department visits and hospitalizations within 14 days as well as the progression to severe disease, defined through the Intensive Care Unit admissions within 14 days, and death within 28 days from the Monoclonal Antibody infusion. From 3898 included patients, 2009 (51.5%) were unvaccinated at the time of Monoclonal Antibody infusion. Unvaccinated patients had more Emergency Department visits (217 vs. 79, p < 0.0001), hospitalizations (116 vs. 38, p < 0.0001), and progression to severe disease (25 vs. 19, p = 0.016) following treatment with Monoclonal Antibody Therapy. After adjustment for demographics and comorbidities, unvaccinated patients were 2.45 times more likely to seek help in the Emergency Department and 2.70 times more likely to be hospitalized. Our data suggest the added benefit between the COVID-19 vaccine and Monoclonal Antibody Therapy.
引用
收藏
页数:10
相关论文
共 50 条
  • [1] Performance of a Triage Protocol for Monoclonal Antibodies in a Mixed Vaccinated and Unvaccinated Cohort of COVID-19 Patients Treated With Intravenous Infusion or Subcutaneous Injection
    Rubin, Emily B.
    Liu, Mofei
    Giobbie-Hurder, Anita
    Canha, Lauren A.
    Keleher, C. Elizabeth
    Sullivan, Keri M.
    Dougan, Michael
    OPEN FORUM INFECTIOUS DISEASES, 2022, 9 (06):
  • [2] COVID-19: Vaccinated versus unvaccinated or not fully vaccinated patients
    Digalaki, A.
    Hillas, G.
    Koukidou, S.
    Sakellaropoulou, A.
    Kosti, C.
    Chrysikos, S.
    Dimakou, K.
    EUROPEAN RESPIRATORY JOURNAL, 2022, 60
  • [3] Comparative Study of Outcomes of COVID-19 Infection in Vaccinated and Unvaccinated Patients- A Retrospective Analysis
    Kakarla, Bhaskar
    Deme, Swaroopa
    Aakula, Sugunasree
    Naini, Abhilash
    Soanker, Radhika
    Modugu, Nageswara Rao
    Ysn, Raju
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2023, 17 (01) : OC9 - OC12
  • [4] Characteristics/Comorbidities of Vaccinated and Unvaccinated Patients With COVID-19
    Roy, A.
    Markan, R.
    Kumar, S.
    Verma, V.
    Kukreja, I
    Gaur, A.
    Chopra, A.
    Nayyar, A.
    Daral, S.
    Pandey, S.
    Mohanty, P.
    Aswal, D.
    VALUE IN HEALTH, 2022, 25 (12) : S461 - S461
  • [5] A retrospective cohort study on early antibiotic use in vaccinated and unvaccinated COVID-19 patients
    Brogna, Carlo
    Montano, Luigi
    Zanolin, Maria Elisabetta
    Bisaccia, Domenico Rocco
    Ciammetti, Gianluca
    Viduto, Valentina
    Fabrowski, Mark
    Baig, Abdul M.
    Gerlach, Joachim
    Gennaro, Iapicca
    Bignardi, Elio
    Brogna, Barbara
    Frongillo, Aquilino
    Cristoni, Simone
    Piscopo, Marina
    JOURNAL OF MEDICAL VIROLOGY, 2024, 96 (03)
  • [6] COVID-19 in vaccinated versus unvaccinated hematologic malignancy patients
    DeVoe, Catherine
    Pandey, Shraddha
    Shariff, Dayana
    Arora, Shagun
    Henrich, Timothy J.
    Yokoe, Deborah S.
    Langelier, Charles R.
    Servellita, Venice
    Chiu, Charles
    Miller, Steve
    Babik, Jennifer M.
    Chin-Hong, Peter
    Fung, Monica
    TRANSPLANT INFECTIOUS DISEASE, 2022, 24 (06)
  • [7] Assessment of unvaccinated and vaccinated patients with coronavirus disease 2019 (COVID-19) treated with monoclonal antibodies during the delta wave (July 1–August 20, 2021): a retrospective observational monocentric study
    Yi Guo
    Kelsie Cowman
    Mei Chang
    Hongkai Bao
    Austin Golia
    Terrence Mcsweeney
    Linda Bard
    Roxanne Simpson
    Erin Andrews
    Liise-anne Pirofski
    Priya Nori
    BMC Infectious Diseases, 22
  • [8] COVID-19 Infection Rates in Vaccinated and Unvaccinated Inmates: A Retrospective Cohort Study
    Ko, Luke
    Malet, Gary
    Chang, Lisa L.
    Nguyen, Huu
    Mayes, Robert
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (09)
  • [9] Clinical outcomes in vaccinated and unvaccinated patients with COVID-19: a population-based analysis
    Papaioannou, O.
    Karampitsakos, T.
    Tsiri, P.
    Sotiropoulou, V.
    Koulousousa, E.
    Tasiopoulos, P.
    Schinas, G.
    Katsaras, M.
    Zarkadi, E.
    Malakounidou, E.
    Georgiopoulou, V.
    Sampsonas, F.
    Spyridonidis, A.
    Akinosoglou, K.
    Marangos, M.
    Tzouvelekis, A.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2022, 26 (20) : 7705 - 7712
  • [10] Mortality and risk factors of vaccinated and unvaccinated frail patients with COVID-19 treated with anti-SARS-CoV-2 monoclonal antibodies: A real-world study
    Nevola, Riccardo
    Feola, Giovanni
    Ruocco, Rachele
    Russo, Antonio
    Villani, Angela
    Fusco, Raffaele
    De Pascalis, Stefania
    Del Core, Micol
    Cirigliano, Giovanna
    Pisaturo, Mariantonietta
    Loffredo, Giuseppe
    Rinaldi, Luca
    Marrone, Aldo
    Starace, Mario
    Sposito, Pellegrino De Lucia
    Cozzolino, Domenico
    Salvatore, Teresa
    Lettieri, Miriam
    Marfella, Raffaele
    Sasso, Ferdinando Carlo
    Coppola, Nicola
    Adinolfi, Luigi Elio
    INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2023, 131 : 155 - 161