Use of guanine-modified glassy carbon electrode as an electrochemical sensor for the determination of paracetamol

被引：4
|
作者：
Islamoglu, Nesim [1 ]
Mulazimoglu, Ayen Demir [1 ]
机构：
[1] Necmettin Erbakan Univ, Ahmet Keleolu Fac Educ, Dept Chem, Konya, Turkiye
来源：
BANGLADESH JOURNAL OF PHARMACOLOGY | 2023年 / 18卷 / 03期
关键词：
VOLTAMMETRIC DETERMINATION; P-AMINOPHENOL; URIC-ACID; ACETAMINOPHEN; NOREPINEPHRINE; QUANTIFICATION; NANOPARTICLES; SURFACE; LIQUID; DRUGS;
D O I：
10.3329/bjp.v18i3.66459
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In this study, guanine-modified glassy carbon electrode sensor was developed for the determination of paracetamol. The use of overdose continuously for a long time, its metabolites accumulate and affect the kidneys and liver. There-fore, the detection of paracetamol is of great significance. Differential pulse voltammetry and cyclic voltammetry techniques were employed to analyze the behavior of paracetamol in 0.1 M Britton-Robinson buffer solution of pH 5.0 on guanine-modified electrode. Guanine-modified glassy carbon electrode showed a good linear response in the concentration range from 0.5 mM to 10 & mu;M for the quantitative determination of paracetamol with the lower limit of detection of 0.9 & mu;M.
引用
收藏
页码：97 / 104
页数：9
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