Use of guanine-modified glassy carbon electrode as an electrochemical sensor for the determination of paracetamol

被引：4

作者：

Islamoglu, Nesim ^{[1
]}

Mulazimoglu, Ayen Demir ^{[1
]}

机构：

[1] Necmettin Erbakan Univ, Ahmet Keleolu Fac Educ, Dept Chem, Konya, Turkiye

来源：

BANGLADESH JOURNAL OF PHARMACOLOGY | 2023年 / 18卷 / 03期

关键词：

VOLTAMMETRIC DETERMINATION; P-AMINOPHENOL; URIC-ACID; ACETAMINOPHEN; NOREPINEPHRINE; QUANTIFICATION; NANOPARTICLES; SURFACE; LIQUID; DRUGS;

D O I：

10.3329/bjp.v18i3.66459

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In this study, guanine-modified glassy carbon electrode sensor was developed for the determination of paracetamol. The use of overdose continuously for a long time, its metabolites accumulate and affect the kidneys and liver. There-fore, the detection of paracetamol is of great significance. Differential pulse voltammetry and cyclic voltammetry techniques were employed to analyze the behavior of paracetamol in 0.1 M Britton-Robinson buffer solution of pH 5.0 on guanine-modified electrode. Guanine-modified glassy carbon electrode showed a good linear response in the concentration range from 0.5 mM to 10 & mu;M for the quantitative determination of paracetamol with the lower limit of detection of 0.9 & mu;M.

引用

页码：97 / 104

页数：9

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