Comparison of Oropharyngeal Dysphagia Before and After Botulinum Toxin Injection in Cervical Dystonia

被引:0
|
作者
Silbergleit, Alice K. [1 ]
Isabell, Krysten [2 ]
Turnbull, Jennifer [1 ]
Patel, Neepa [3 ,4 ]
Boettcher, Erica [1 ]
Konnai, Ramya [1 ]
Collins, Denise [5 ]
Sidiropoulos, Christos [6 ]
Schultz, Lonni [7 ]
机构
[1] Henry Ford Hlth, Dept Neurol, Div Speech Language Sci & Disorders, 6777 West Maple Rd, W Bloomfield, MI 48322 USA
[2] Henry Ford Hlth, Dept Neurol, Div Speech Language Sci & Disorders, 2799 West Grand Blvd, Detroit, MI 48202 USA
[3] Henry Ford Hlth, Dept Neurol, Div Movement Disorders, 6777 West Maple Rd, W Bloomfield, MI 48322 USA
[4] Rush Univ, Med Ctr, Dept Neurol, 1620 W Harrison St, Chicago, IL 60612 USA
[5] Henry Ford Hlth, Dept Diagnost Radiol, 6777 West Maple Rd, West Bloomfield, MI 48322 USA
[6] Michigan State Univ, Dept Neurol, 788 Serv Rd,Room B-446, E Lansing, MI 48824 USA
[7] Henry Ford Hlth, Dept Publ Hlth Sci, One Ford Pl, Detroit, MI 48202 USA
关键词
Cervical dystonia; Botulinum toxin injections; Dysphagia; Videofluoroscopy; Patient reported outcomes measures; QUALITY-OF-LIFE; ADULT-ONSET; SPASMODIC TORTICOLLIS; SWALLOWING FUNCTION; CEREBELLAR; NETWORKS;
D O I
10.1007/s00455-023-10571-4
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
Cervical dystonia (CD) is the most common form of focal dystonia with Botulinum neurotoxin (BoNT) being a frequent method of treatment. Dysphagia is a common side effect of BoNT treatment for CD. Instrumental evaluation of swallowing in CD using standardized scoring for the videofluoroscopic swallowing study (VFSS) and validated and reliable patient-reported outcomes measures is lacking in the literature. (1) to determine if BoNT injections change instrumental findings of swallowing function using the Modified Barium Swallow Impairment Profile (MBSImP) in individuals with CD; (2) to determine if BoNT injections change self-perception of the psychosocial handicapping effects of dysphagia in individuals with CD, using the Dysphagia Handicap Index (DHI); (3) to determine the effect of BoNT dosage on instrumental swallowing evaluation and self-reported swallowing outcomes measures. 18 subjects with CD completed a VFSS and the DHI before and after BoNT injection. There was a significant increase in pharyngeal residue for pudding consistency after BoNT injection, p = 0.015. There were significant positive associations between BoNT dosage and self-perception of the physical attributes of the handicapping effect of dysphagia, the grand total score and patient self-reported severity of dysphagia on the DHI; p = 0.022; p = 0.037; p = 0.035 respectively. There were several significant associations between changes in MBSImP scores and BoNT dose. Pharyngeal efficiency of swallowing may be affected by BoNT for thicker consistencies. Individuals with CD perceive greater physical handicapping effects of dysphagia with increased amounts of BoNT units and have greater self-perceptions of dysphagia severity with increased amounts of BoNT units.
引用
收藏
页码:1421 / 1429
页数:9
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