EWSR1::NR4A3 gene fusion in a cutaneous atypical myoepithelial neoplasm

被引：1
|
作者：
Scholl, Ashley Rose [1 ]
Kliassov, Evelyna [1 ]
Cardona, Diana M. [1 ]
Bentley, Rex [1 ]
Al-Rohil, Rami N. [1 ,2 ,3 ]
机构：
[1] Duke Univ Hosp, Dept Pathol, Durham, NC USA
[2] Duke Univ Hosp, Dept Dermatol, Durham, NC USA
[3] Duke Univ, Med Ctr, Dept Pathol & Dermatol, Div Dermatopathol, 40 Duke Med Circle, Durham, NC 27710 USA
来源：
JOURNAL OF CUTANEOUS PATHOLOGY | 2023年 / 50卷 / 07期
关键词：
EWSR; myoepithelial carcinoma; soft tissue tumors; EXTRASKELETAL MYXOID CHONDROSARCOMA; SOFT-TISSUE; CARCINOMA; SPECTRUM;
D O I：
10.1111/cup.14429
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Myoepithelial neoplasms of the skin and soft tissue are rare and share histopathologic features with their salivary gland counterpart. We present a case of an atypical myoepithelial neoplasm from the back of a 72-year-old female. This lesion harbored an EWSR1::NR4A3 gene fusion, a genetic signature characteristically seen in extraskeletal myxoid chondrosarcoma. To our knowledge, this is a unique case of an atypical cutaneous myoepithelial neoplasm harboring EWSR1::NR4A3 fusion.
引用
收藏
页码：601 / 605
页数：5
相关论文
共 50 条
  • [41] Analysing the gene expression profiles of the orphan nuclear receptors NR4A1, NR4A2 and NR4A3 in premalignant lesions of the cervix and cervicitis
    Cruz-Nieves, Rosa P.
    Ramirez-Rosales, Gladys E.
    Gonzalez-Ramirez, Javier
    Sanchez-Munoz, Fausto
    Ruiz-Hernandez, Armando
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X, 2024, 24
  • [42] Characterization of a novel sarcoma cell line with an EWSR1::POU2AF3 fusion
    Schwab, Hannah
    Kerkhoff, Maximilian
    Plaumann, Pauline
    Collaud, Stephane
    Dirksen, Uta
    Theegarten, Dirk
    Herold, Thomas
    Kalbourtzis, Stavros
    Boeluekbas, Servet
    Hegedues, Balazs
    Hegedues, Luca
    PATHOLOGY & ONCOLOGY RESEARCH, 2025, 31
  • [43] The Nuclear Orphan Receptor NR4A1 and NR4A3 as Tumor Suppressors in Hematologic Neoplasms
    Wenzl, Kerstin
    Troppan, Katharina
    Neumeister, Peter
    Deutsch, Alexander J. A.
    CURRENT DRUG TARGETS, 2015, 16 (01) : 38 - 46
  • [44] Clear Cell Odontogenic Carcinoma Harboring the EWSR1–ATF1 Fusion Gene: Report of a Rare Case
    Thalita Santana
    Felipe Ledo de Andrade
    Maria Carolina de Sousa Melo
    Glauber Bareia Liberato da Rocha
    Marília Trierveiler
    Head and Neck Pathology, 2020, 14 : 847 - 851
  • [45] POTENTIAL ROLE OF NUCLEAR ORPHAN RECEPTORS NR4A1 AND NR4A3 IN HUMAN CHONDROCYTES
    Angerer, H.
    Krusch, D.
    Deutsch, A.
    Gruber, G.
    Setznagl, D.
    Kremser, M. L.
    Leithner, A.
    Stradner, M. H.
    Graninger, W. B.
    OSTEOARTHRITIS AND CARTILAGE, 2012, 20 : S140 - S140
  • [46] A novel fusion variant LSM14A::NR4A3 in extraskeletal myxoid chondrosarcoma
    Ngo, Carine
    Verret, Benjamin
    Vibert, Julien
    Cotteret, Sophie
    Levy, Antonin
    Le Pechoux, Cecile
    Haddag-Miliani, Leila
    Honore, Charles
    Faron, Matthieu
    Quinquis, Fabien
    Le Cesne, Axel
    Scoazec, Jean-Yves
    Pierron, Gaelle
    GENES CHROMOSOMES & CANCER, 2023, 62 (01): : 52 - 56
  • [47] A cryptic EWSR1::DDIT3 fusion in myxoid liposarcoma: Potential pitfalls with FISH and cytogenetics
    Ibstedt, Sebastian
    Rego de Mattos, Camila Bedeschi
    Koster, Jan
    Mertens, Fredrik
    GENES CHROMOSOMES & CANCER, 2023, 62 (03): : 167 - 170
  • [48] EWSR1-POU5F1 Fusion in Soft Tissue Myoepithelial Tumors. A Molecular Analysis of Sixty-Six Cases, Including Soft Tissue, Bone, and Visceral Lesions, Showing Common Involvement of the EWSR1 gene
    Antonescu, Cristina R.
    Zhang, Lei
    Chang, Ning-En
    Pawel, Bruce R.
    Travis, William
    Katabi, Nora
    Edelman, Morris
    Rosenberg, Andrew E.
    Nielsen, G. Petur
    Dal Cin, Paola
    Fletcher, Christopher D. M.
    GENES CHROMOSOMES & CANCER, 2010, 49 (12): : 1114 - 1124
  • [49] Novel EWSR1-POU5F1 Fusion in Soft Tissue Myoepithelial Tumors. A Molecular Analysis of 29 Cases, Including Soft Tissue, Bone and Visceral Locations Showing Common Involvement of EWSR1 Gene Rearrangement
    Antonescu, C. R.
    Zhang, L.
    Chang, N. E.
    Pawel, B. R.
    Travis, W.
    Rosenberg, A. E.
    Nielsen, G. P.
    Dal Cin, P.
    Fletcher, C. D.
    MODERN PATHOLOGY, 2010, 23 : 14A - 15A
  • [50] Novel EWSR1-POU5F1 Fusion in Soft Tissue Myoepithelial Tumors. A Molecular Analysis of 29 Cases, Including Soft Tissue, Bone and Visceral Locations Showing Common Involvement of EWSR1 Gene Rearrangement
    Antonescu, C. R.
    Zhang, L.
    Chang, N. E.
    Pawel, B. R.
    Travis, W.
    Rosenberg, A. E.
    Nielsen, G. P.
    Dal Cin, P.
    Fletcher, C. D.
    LABORATORY INVESTIGATION, 2010, 90 : 14A - 15A
12345