Behavioral sex differences primarily derive from the sexually dimorphic organization of neural circuits that direct the behavior. In Drosophila melanogaster, the sex-determination genes fruitless (fru) and doublesex (dsx) play pivotal roles in producing the sexual dimorphism of neural circuits for behavior. Here we examine three neural groups expressing fru and/or dsx, i.e., the P1 cluster, aSP-f and aSP-g cluster pairs and aDN cluster, in which causal relationships between the dimorphic behavior and dimorphic neural characteristics are best illustrated. aSP-f, aSP-g and aDN clusters represent examples where fru or dsx switches cell-autonomously their neurite structures between the female-type and male-type. Processed sensory inputs impinging on these neurons may result in outputs that encode different valences, which culminate in the execution of distinct behavior according to the sex. In contrast, the P1 cluster is male-specific as its female counterpart undergoes dsx-driven cell death, which lowers the threshold for the induction of male-specific behaviors. We propose that the products of fru and dsx genes, as terminal selectors in sexually dimorphic neuronal wiring, induce and maintain the sex-typical chromatin state at postembryonic stages, orchestrating the transcription of effector genes that shape single neuron structures and govern cell survival and death.
机构:
Pontifical Catholic Univ Rio Grande Do Sul PUCRS, Brain Inst Rio Grande Do Sul, Sch Med, Dev Cognit Neurosci Lab, Porto Alegre, RS, BrazilPontifical Catholic Univ Rio Grande Do Sul PUCRS, Brain Inst Rio Grande Do Sul, Sch Med, Dev Cognit Neurosci Lab, Porto Alegre, RS, Brazil
Kestering-Ferreira, Erika
Heberle, Bernardo Aguzzoli
论文数: 0引用数: 0
h-index: 0
机构:
Univ Kentucky, Coll Med, Dept Neurosci, Lexington, KY USAPontifical Catholic Univ Rio Grande Do Sul PUCRS, Brain Inst Rio Grande Do Sul, Sch Med, Dev Cognit Neurosci Lab, Porto Alegre, RS, Brazil
Heberle, Bernardo Aguzzoli
论文数: 引用数:
h-index:
机构:
Lumertz, Francisco Sindermann
Gobira, Pedro Henrique
论文数: 0引用数: 0
h-index: 0
机构:
Aarhus Univ, Dept Clin Med, Translat Neuropsychiat Unit, Aarhus, DenmarkPontifical Catholic Univ Rio Grande Do Sul PUCRS, Brain Inst Rio Grande Do Sul, Sch Med, Dev Cognit Neurosci Lab, Porto Alegre, RS, Brazil
Gobira, Pedro Henrique
Orso, Rodrigo
论文数: 0引用数: 0
h-index: 0
机构:
Univ Milan, Dept Pharmacol & Biomol Sci, Milan, ItalyPontifical Catholic Univ Rio Grande Do Sul PUCRS, Brain Inst Rio Grande Do Sul, Sch Med, Dev Cognit Neurosci Lab, Porto Alegre, RS, Brazil
Orso, Rodrigo
论文数: 引用数:
h-index:
机构:
Grassi-Oliveira, Rodrigo
Viola, Thiago Wendt
论文数: 0引用数: 0
h-index: 0
机构:
Pontifical Catholic Univ Rio Grande Do Sul PUCRS, Brain Inst Rio Grande Do Sul, Sch Med, Dev Cognit Neurosci Lab, Porto Alegre, RS, BrazilPontifical Catholic Univ Rio Grande Do Sul PUCRS, Brain Inst Rio Grande Do Sul, Sch Med, Dev Cognit Neurosci Lab, Porto Alegre, RS, Brazil
机构:
Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Div Brain Sci, London W12 0NN, EnglandUniv London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Div Brain Sci, London W12 0NN, England
Gillies, G. E.
Virdee, K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England
Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, EnglandUniv London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Div Brain Sci, London W12 0NN, England
Virdee, K.
Mcarthur, S.
论文数: 0引用数: 0
h-index: 0
机构:
Barts & London Queen Marys Sch Med & Dent, William Harvey Res Inst, London EC1 6BQ, EnglandUniv London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Div Brain Sci, London W12 0NN, England
Mcarthur, S.
Dalley, J. W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England
Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England
Univ Cambridge, Addenbrookes Hosp, Dept Psychiat, Cambridge CB2 2QQ, EnglandUniv London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Div Brain Sci, London W12 0NN, England
机构:
Univ Lille, CNRS, UMR 8576, Unite Glycobiol Struct & Fonct, Campus Cite Sci, Lille, France
Univ Lille, Sapienza Univ Rome, Int Associated Lab LIA Prenatal Stress & Neurodeg, IRCCS Neuromed,CNRS,UMR 8576, Rome, ItalyUniv Lille, CNRS, UMR 8576, Unite Glycobiol Struct & Fonct, Campus Cite Sci, Lille, France
Van Camp, Gilles
Reynaert, Marie-Line
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille, CNRS, UMR 8576, Unite Glycobiol Struct & Fonct, Campus Cite Sci, Lille, FranceUniv Lille, CNRS, UMR 8576, Unite Glycobiol Struct & Fonct, Campus Cite Sci, Lille, France
Reynaert, Marie-Line
Gatta, Eleonora
论文数: 0引用数: 0
h-index: 0
机构:
Univ Illinois, Dept Psychiat, Coll Med, Psychiat Inst,Ctr Alcohol Res Epigenet, Chicago, IL 60612 USAUniv Lille, CNRS, UMR 8576, Unite Glycobiol Struct & Fonct, Campus Cite Sci, Lille, France
Gatta, Eleonora
Marrocco, Jordan
论文数: 0引用数: 0
h-index: 0
机构:
Rockefeller Univ, Lab Neuroendocrinol, 1230 York Ave, New York, NY 10021 USAUniv Lille, CNRS, UMR 8576, Unite Glycobiol Struct & Fonct, Campus Cite Sci, Lille, France
Marrocco, Jordan
Bouwalerh, Hammou
论文数: 0引用数: 0
h-index: 0
机构:
Univ Lille, CNRS, UMR 8576, Unite Glycobiol Struct & Fonct, Campus Cite Sci, Lille, France
Univ Lille, Sapienza Univ Rome, Int Associated Lab LIA Prenatal Stress & Neurodeg, IRCCS Neuromed,CNRS,UMR 8576, Rome, ItalyUniv Lille, CNRS, UMR 8576, Unite Glycobiol Struct & Fonct, Campus Cite Sci, Lille, France
Bouwalerh, Hammou
Nicoletti, Ferdinando
论文数: 0引用数: 0
h-index: 0
机构:
Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Rome, Italy
NEUROMED, IRCCS, Pozzilli, Italy
Univ Lille 1, CNRS, Int Associated Lab LIA, Rome, Italy
Sapienza Univ Rome, IRCCS Neuromed, Rome, ItalyUniv Lille, CNRS, UMR 8576, Unite Glycobiol Struct & Fonct, Campus Cite Sci, Lille, France