Transition-metal-free radical phosphorylation/cyclization of unactivated alkenes: Access to phosphine-containing quinazolinones

被引：5
|
作者：
Gao, Shenyuan [1 ]
Guo, Jia [1 ,2 ]
Yang, Jianhai [1 ,2 ]
Wang, Xiaozhong [1 ,2 ]
Xu, Cai [1 ,2 ]
Chen, Yingqi [1 ,2 ]
Dai, Liyan [1 ,2 ]
机构：
[1] Zhejiang Univ, Coll Chem & Biol Engn, Zhejiang Prov Key Lab Adv Chem Engn Manufacture Te, Hangzhou 310027, Peoples R China
[2] Inst Zhejiang Univ Quzhou, Quzhou 324000, Peoples R China
来源：
TETRAHEDRON | 2023年 / 148卷
关键词：
DERIVATIVES; FEBRIFUGINE; INHIBITION;
D O I：
10.1016/j.tet.2023.133669
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new cascade radical addition/cyclization of unactivated alkenes and phosphine oxides has been developed. A wide variety of bioactive phosphine-containing quinazolinones were obtained in up to 91% yield for 34 examples under transition-metal-free conditions. This cascade protocol represents an environmentally friendly and efficient way to build phosphine-containing quinazolinones in excellent yields under mild conditions with a broad substrate scope and high atomic economy.
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页数：11
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