We study the cohomology of group theoretic Dehn fillings. Applying the Cohen-Lyndon property for sufficiently deep Dehn fillings of hyperbolically embedded subgroups H (sic)(h) G, obtained by the second named author in [67], we derive a spectral sequence that computes the cohomology of the corresponding Dehn filling quotients (G) over bar. As an application, we establish an isomorphism between the relative cohomology of the group pair (G, H) and its sufficiently deep Dehn filling quotient pair ((G) over bar, (H) over bar). This allows us to generalize the results of Fujiwara and Manning on simplicial volume of Dehn fillings of hyperbolic manifolds to Dehn fillings of Poincare duality pairs. We also strengthen the results of Olshanskii [58], Dahmani-Guirardel-Osin [27] and Hull [42] on SQ-universality and common quotients of acylindrically hyperbolic groups by adding cohomological finiteness conditions. We apply these results to obtain hyperbolic and acylindrically hyperbolic quotients with special properties. (c) 2023 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org /licenses /by-nc-nd /4.0/).