NHC-catalyzed [12+2] reaction of polycyclic arylaldehydes for access to indole derivatives

被引：5

作者：

Ji, Hong ^{[1
]}

Zou, Juan ^{[2
]}

Mou, Chengli ^{[2
]}

Liu, Yonggui ^{[1
]}

Ren, Shi-Chao ^{[1
]}

Chi, Yonggui Robin ^{[1
,3
]}

机构：

[1] Guizhou Univ, Natl Key Lab Green Pesticide, Key Lab Green Pesticide & Agr Bioengn, Minist Educ, Guiyang 550025, Peoples R China

[2] Guiyang Coll Tradit Chinese Med, Sch Pharm, Guiyang 550025, Peoples R China

[3] Nanyang Technol Univ, Sch Chem Chem Engn & Biotechnol, Singapore 637371, Singapore

来源：

CHEMICAL COMMUNICATIONS | 2023年 / 59卷 / 42期

关键词：

CYCLOADDITIONS; ANNULATION;

D O I：

10.1039/d3cc00999h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An N-heterocyclic carbene (NHC) catalyzed enantio- and diastereoselective [12+2] cycloaddition is disclosed to rapidly construct sophisticated molecules bearing a tricyclic core and morpholine moiety. The success of our reaction relies on the NHC-catalyzed remote sp(3) (C-H) bond activation of a 5H-benzo[a]pyrrolizine-3-carbaldehyde under oxidative conditions. Preliminary studies revealed that our products exhibit superior in vitro bioactivities against two plant pathogens to commercial Bismerthiazol (BT) and Thiodiazole Copper (TC).

引用

页码：6351 / 6354

页数：4

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