FeCl3-catalyzed Friedel-Crafts alkylation of 2-substituted furans with 2-nitrobenzhydrols

被引：1
|
作者：
Merkushev, Anton A. [1 ]
Eshmemet'eva, Diana A. [1 ]
Uchuskin, Maxim G. [1 ]
机构：
[1] Perm State Univ, Bukireva St 15, Perm 614990, Russia
来源：
TETRAHEDRON | 2023年 / 145卷
基金：
俄罗斯科学基金会;
关键词：
Friedel -Crafts alkylation; 2-Nitrobenzhydrols; Furan; 2-(2-Nitrobenzyl)furans; POLYSUBSTITUTED INDOLES; DOMINO REACTION; SIMPLE ROUTE; ALCOHOLS; RING; RECYCLIZATION; DERIVATIVES; ACCESS; REARRANGEMENT;
D O I：
10.1016/j.tet.2023.133627
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have developed a FeCl3-catalyzed protocol for the Friedel-Crafts alkylation of 2-substituted furans with 2-nitrobenzhydrols. The described method allows for synthesizing 2-(2-nitrobenzyl)furans in good to high yields. We also demonstrated the synthetic utility of obtained 2-(2-nitrobenzyl)furan, which could be used for the synthesis of substituted oxazino[2,3-a]indole.
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页数：6
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