Challenges of Glycemic Control in People With Diabetes and Advanced Kidney Disease and the Potential of Automated Insulin Delivery

被引：1

作者：

Lu, Jean C. ^{[1
,2
,3
]}

Lee, Petrova ^{[4
]}

Ierino, Francesco ^{[1
,4
,5
]}

MacIsaac, Richard J. ^{[1
,2
,3
]}

Ekinci, Elif ^{[3
,6
,7
]}

O'Neal, David ^{[1
,2
,3
]}

机构：

[1] Univ Melbourne, St Vincents Hosp Melbourne, Dept Med, Fitzroy, Vic, Australia

[2] St Vincents Hosp Melbourne, Dept Endocrinol & Diabet, Fitzroy, Vic, Australia

[3] Australian Ctr Accelerating Diabet Innovat, Univ Melbourne, Parkville, Vic, Australia

[4] St Vincents Hosp Melbourne, Dept Nephrol, Fitzroy, Vic, Australia

[5] St Vincents Inst Med Res, Fitzroy, Vic, Australia

[6] Dept Endocrinol & Diabet, Austin, Vic, Australia

[7] Univ Melbourne, Austin Hosp, Dept Med, Heidelberg, Vic, Australia

来源：

JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY | 2024年 / 18卷 / 06期

基金：

英国医学研究理事会;

关键词：

diabetes; automated insulin delivery; insulin pump; chronic kidney disease; dialysis; artificial pancreas; HEMODIALYSIS-INDUCED HYPOGLYCEMIA; HYBRID CLOSED-LOOP; PERITONEAL-DIALYSIS; COGNITIVE FUNCTION; GLUCOSE; IMPACT; METABOLISM; RESISTANCE; SURVIVAL; MELLITUS;

D O I：

10.1177/19322968231174040

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Diabetes is the leading cause of chronic kidney disease (CKD) and end-stage kidney disease in the world. It is known that maintaining optimal glycemic control can slow the progression of CKD. However, the failing kidney impacts glucose and insulin metabolism and contributes to increased glucose variability. Conventional methods of insulin delivery are not well equipped to adapt to this increased glycemic lability. Automated insulin delivery (AID) has been established as an effective treatment in patients with type 1 diabetes mellitus, and there is emerging evidence for their use in type 2 diabetes mellitus. However, few studies have examined their role in diabetes with concurrent advanced CKD. We discuss the potential benefits and challenges of AID use in patients with diabetes and advanced CKD, including those on dialysis.

引用

页码：1500 / 1508

页数：9

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