Green synthesis of gold nanoparticles using potato starch as a phytochemical template, green reductant and stabilizing agent and investigating its cytotoxicity, antioxidant and anti-ovarian cancer effects

Herein we have demonstrated a sustainable pathway for the Au nanoparticles synthesis using potato starch as a phytochemical template, green reductant and stabilizing agent. The reaction was initiated by ultrasound irradiation as a non-conventional source of energy. As-synthesized nanocomposite material (Starch/Au NPs) physicochemical characteristics was determined over several analytical techniques like TEM, UV-Vis, SEM, XRD and EDX. The in vitro cytotoxic and anti-ovarian potentials of biologically synthesized Starch/Au nanocomposite were assessed against OVCAR-3 and OVCAR-4 cancer cells. The anti-ovarian cancer activities of the Starch/Au nanocomposite were validated by the significant diminishing of OVCAR-3 and OVCAR-4 cancer cells. The IC50 of the Starch/Au nanocomposite were found as 285 and 189 & mu;g/mL respectively against the said cell lines. The outstanding results of this current research definitely could lead the biologically synthesized Starch/Au nancomposite as a potential adjuvant chemopreventive and chemotherapeutic agent to cure the ovarian cancer. The material also exhibited significant antioxidant properties. However, it necessitates in vivo animal studies to ascertain further evidences as anti-ovarian cancer agents.