Copper(II)-Catalyzed Enantioselective Aza-Friedel-Crafts Reaction of Indoles with Isatin-Derived N-Boc-Ketimines

被引：4
|
作者：
Xue, Leipeng [1 ,2 ]
Hou, Jiaqi [1 ,2 ]
Li, Jiahui [1 ,2 ]
Yu, Tianxu [1 ,2 ]
Cai, Qihang [1 ,2 ]
Yu, Shibo [1 ,2 ]
Yao, Chao [1 ,2 ]
Li, Yue-Ming [1 ,2 ]
机构：
[1] Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China
[2] Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 88卷 / 20期
基金：
中国国家自然科学基金;
关键词：
NATURAL-PRODUCTS; SPIROINDOLONES; ALKALOIDS; POTENT;
D O I：
10.1021/acs.joc.3c01144
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The copper(II)-catalyzed enantioselective aza-Friedel-Crafts reaction of indoles with isatin-derived N-Boc-ketimines was developed by using tunable chiral O-N-N tridentate ligands derived from BINOL and proline. In general, the reaction afforded chiral 3-indolyl-3-aminooxindoles under mild conditions in high yields (83-97%) with excellent ee (69-99%).
引用
收藏
页码：14345 / 14350
页数：6
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