The synthesis and antitubercular activity of 4,5-dihydro-1H-pyrazole derivatives with a basic epoxybenzo[7,8]oxocine framework

被引：0
|
作者：
Stalinskaya, Alena L. [1 ]
Dengis, Natalia A. [2 ]
Vlasenko, Vasily S. [2 ]
Kulakov, Ivan V. [1 ]
机构：
[1] Univ Tyumen, Sch Nat Sci, 15a Perekopskaya St, Tyumen 625003, Russia
[2] Omsk Agr Sci Ctr, 26 Koroleva Ave, Omsk 644012, Russia
来源：
CHEMISTRY OF HETEROCYCLIC COMPOUNDS | 2024年 / 60卷 / 1-2期
基金：
俄罗斯科学基金会;
关键词：
4,5-dihydro-1H-pyrazoles; epoxybenzo[7,8]oxocino[4,3-b]pyridines; pyridyl chalcones; antitubercular activity; BENZOFURAN OXIDATIVE DEAROMATIZATION; BIOLOGICAL EVALUATION; PYRAZOLINE DERIVATIVES; ANTIMICROBIAL ACTIVITY; POTENT ANTIOXIDANTS; ANTICANCER ACTIVITY; TETRACYCLIC CORE; DESIGN; INTEGRASTATINS; 3,5-DIACETYL-2,6-DIMETHYLPYRIDINE;
D O I：
10.1007/s10593-024-03291-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The corresponding pyridyl chalcones were synthesized by the aldol-crotonic condensation of the acetyl derivative of epoxybenzo[7,8]-oxocino[4,3-b]pyridine with aromatic aldehydes. A subsequent cyclization with hydrazine hydrate in acetic acid led to the corresponding 4,5-dihydro-1H-pyrazole derivatives. An assessment of the resulting derivatives for antitubercular activity was carried out.
引用
收藏
页码：41 / 47
页数：7
相关论文
共 50 条
  • [21] Synthesis and monoamine oxidase inhibitory activities of 1-thiocarbamoyl-3,5-diphenyl-4,5-dihydro-1H-pyrazole derivatives
    Palaska, Erhan
    Aydin, Firat
    Ucar, Guelberk
    Erol, Dilek
    ARCHIV DER PHARMAZIE, 2008, 341 (04) : 209 - 215
  • [22] 1-(4-Methylphenylsulfonyl)-5-phenyl-4,5-dihydro-1H-pyrazole
    Li, Jie
    Zhao, Wei
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O1898 - U1752
  • [23] Synthesis, biological evaluation and 3D-QSAR studies of novel 4,5-dihydro-1H-pyrazole niacinamide derivatives as BRAF inhibitors
    Li, Cui-Yun
    Li, Qing-Shan
    Yan, Li
    Sun, Xiao-Guang
    Wei, Ran
    Gong, Hai-Bin
    Zhu, Hai-Liang
    BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (12) : 3746 - 3755
  • [24] Synthesis and selective antitubercular and antimicrobial inhibitory activity of 1-acetyl-3,5-diphenyl-4,5-dihydro-(1H)-pyrazole derivatives
    Chovatia, P. T.
    Akabari, J. D.
    Kachhadia, P. K.
    Zalavadia, P. D.
    Joshi, H. S.
    JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 2006, 71 (07) : 713 - 720
  • [25] 3,5-Bis(4-bromophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
    Samshuddin, S.
    Narayana, B.
    Yathirajan, H. S.
    Safwan, A. P.
    Tiekink, Edward R. T.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1279 - U299
  • [26] 3,5-Bis(4-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
    Jasinski, Jerry P.
    Guild, Curtis J.
    Samshuddin, S.
    Narayana, B.
    Yathirajan, H. S.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2010, 66 : O1948 - U607
  • [27] 3,5-Bis(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
    Butcher, Ray J.
    Akkurt, Mehmet
    Samshuddin, S.
    Narayana, B.
    Yathirajan, H. S.
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2011, 67 : O1019 - U1765
  • [28] 3,5-Bis(4-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole
    Baktir, Zeliha
    Akkurt, Mehmet
    Samshuddin, S.
    Narayana, B.
    Yathirajan, H. S.
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2011, 67 : O328 - U295
  • [29] Synthesis and antihepatotoxic activity of 5-(2,3-dihydro-1,4-benzodioxane-6-yl)-3-substituted-phenyl-4,5-dihydro-1H-pyrazole derivatives
    Khalilullah, Habibullah
    Khan, Shamshir
    Ahsan, Mohamed Jawed
    Ahmed, Bahar
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (24) : 7251 - 7254
  • [30] 3,5-Bis(4-fluorophenyl)-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrazole
    Samshuddin, Seranthimata
    Narayana, Badiadka
    Yathirajan, Hemmige S.
    Gerber, Thomas
    Hosten, Eric
    Betz, Richard
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2012, 68 : O3216 - +
12345