Targeting Strategies for Site-Specific mRNA Delivery

被引：7

作者：

Di, Jiaxing ^{[1
]}

Huang, Pei ^{[2
,3
,4
,5
,6
,7
]}

Chen, Xiaoyuan ^{[2
,3
,4
,5
,6
,7
,8
,9
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai 200240, Peoples R China

[2] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Diagnost Radiol, Singapore 119074, Singapore

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Surg, Singapore 119074, Singapore

[4] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Chem & Biomol Engn, Singapore 119074, Singapore

[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Biomed Engn, Singapore 119074, Singapore

[6] Natl Univ Singapore, Coll Design & Engn, Singapore 119074, Singapore

[7] Natl Univ Singapore, Yong Loo Lin Sch Med, Nanomed Translat Res Program, Singapore 117597, Singapore

[8] Natl Univ Singapore, Clin Imaging Res Ctr, Ctr Translat Med, Yong Loo Lin Sch Med, Singapore 117599, Singapore

[9] ASTAR, Inst Mol & Cell Biol, Singapore 138673, Singapore

来源：

BIOCONJUGATE CHEMISTRY | 2024年 / 35卷 / 04期

基金：

新加坡国家研究基金会; 英国医学研究理事会;

关键词：

LIPID NANOPARTICLES;

D O I：

10.1021/acs.bioconjchem.4c00038

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

mRNA therapeutics hold great promise for disease treatment, yet a key challenge lies in achieving site-specific mRNA delivery to maximize therapeutic efficacy while minimizing off-target side effects. This viewpoint delves into multiple complementary targeting strategies to achieve precise site-specific mRNA delivery, covering topics of administration routes, passive targeting, and active targeting. It highlights the critical importance of rationally designed nanocarriers for obtaining desired therapeutic effects and accelerating the clinical translation of mRNA therapeutics. [GRAPHICS]

引用

页码：453 / 456

页数：4

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